Molecular Neurobiology Synaptic Plasticity



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Selected Publications 

Schwenk, J., Pérez-Garci, E., Schneider, A., Kollewe, A., Gauthier-Kemper, A., Fritzius, T., Raveh, A., Dinamarca, M.C., Hanuschkin, A., Bildl, W., Klingauf, J., Gassmann, M., Schulte, U., Bettler, B.*, Fakler, B.* (2016) Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics. Nat Neurosci. 19, 233-242. * corresponding authors

Turecek, R., Schwenk, J., Fritzius, T., Ivankova, K., Zolles, G., Adelfinger, L., Jacquier, V., Besseyrias, V., Gassmann, M., Schulte, U., Fakler, B., Bettler, B. (2014) Auxiliary GABAB receptor subunits uncouple G Protein βγ subunits from effector channels to induce desensitization. Neuron 82(5), 1032-1044.

Gassmann, M. and Bettler, B. (2012). Regulation of neuronal GABAB receptor functions by subunit composition. Nature Reviews Neuroscience 13, 380-394.

Dill, M.T., Tornillo, L., Fritzius, T., Terracciano, L., Semela, D., Bettler, B.*, Heim M.H.*, and Tchorz, J.S*. (2013). Constitutive Notch2 signaling induces hepatic tumors in mice. Hepatology 57(4), 1607-1619. *Corresponding authors.

Guetg, N., Abdel Aziz, S., Holbro, N., Turecek R., Rose, T., Seddik, R., Gassmann, M., Moes, S., Jenoe, P, Oertner, T.G., Casanova, E. and Bettler, B. (2010). NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1. Proc. Natl. Acad. Sci. USA 107(31), 13924-13929.

Schwenk, J., Metz, M., Zolles, G., Turecek, R., Fritzius, T., Bidl, W., Tarusawa, E., Kulik, A., Unger, A., Ivankova, K., Seddik, R., Tiao, J.Y., Rajalu, M., Trojanova, J., Gassmann, M., Schulte, U., Fakler, B. and Bettler, B. (2010). Native GABAB receptors are heteromultimers with a family of auxiliary subunits. Nature 465(7295), 231-235.

Biermann, B., Bradaia A., Ivankova-Susankova, K., Besseyrias, V., Abdel Aziz, S., Kapfhammer, J.P., Gassmann, M. and Bettler, B. (2010). The sushi domains of GABAB receptors function as dominant axonal targeting signals. J. Neurosci. 30(4), 1385-1394.

Bradaia, A., Trube, G., Stalder, H., Norcross, R.D., Ozmen, L., Wettstein, J.G., Pinard A., Buchy D., Gassmann, M., Hoener, M.C. and Bettler, B. (2009). The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc. Natl. Acad. Sci. USA 106(47), 20081-20086.

Tchorz, J.S., Kinter J., Müller, M., Tornillo, L., Heim, M.H. and Bettler, B. (2009). Notch2 signaling is sufficient to specify biliary epithelial cell fate and to induce tubulogenesis during intrahepatic bile duct development. Hepatology 50(3), 871-879.

Guetg, N., Seddik, R., Vigot, R., Gassmann, M., Vogt, K., Shigemoto, R., Kretz, O., Frotscher, M., Kulik, A., and Bettler, B. (2009). The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses. J. Neurosci. 29(5), 1414-1423.

Matsuki, T., Nomiyama, M., Takahira, H., Hirashima, N., Kilduff, T.S., Kunita, S., Takahashi, S., Yagami, K., Bettler, B., Yanagisawa, M., and Sakurai, T. (2009). Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture. Proc. Natl. Acad. Sci. USA 106(11), 4459-4464. Comment in Cell 137,3 389 (2009).

Vigot, R., Barbieri, S., Bräuner-Osborne, H., Turecek, R., Shigemoto, R., Zhang, Y.-P., Luján, R., Jacobson, L.H., Biermann, B., Fritschy, J.-M., Vacher, C.-M., Müller, M., Sansig, G., Guetg, N., Cryan, J.F., Kaupmann, K., Gassmann, M., Oertner, T.G. and Bettler, B. (2006). Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron 50(4), 589-601. Highlighted in: Neuron 50(4), 521-524, 2006; Nature 44, 387, 2006; Nature Reviews 7, 506, 2006.

Pérez-Garci, E., Gassmann, M., Bettler, B. and Larkum. M. E. (2006). The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons. Neuron 50(4), 603-16.

Shaban, H., Humeau, Y., Herry, C., Cassasus, G., Shigemoto, R., Ciocchi, S., Barbieri, S. van der Putten, H., Kaupmann, K., Bettler, B. and Lüthi. A. (2006). Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nature Neurosci. 9(8), 1028-1035.

Tabata, T., Araishi, K., Hashimoto, K., Hashimotodani, Y., Van der Putten, H., Bettler, B. and Kano, M. (2004). Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA. Proc. Natl. Acad. Sci. USA 101, 16952-16957.

Gassmann, M., Shaban, H., Vigot, R., Sansig, G., Haller, C., Barbieri, S., Humeau, Y., Schuler, V., Müller, M., Kinzel, B., Klebs, K., Schmutz, M. , Froestl, W., Heid, J., Kelly, P. H., Gentry, C., Jaton, A.-L., Van der Putten, H., Mombereau, C., Lecourtier, L., Mosbacher, J., Cryan, J. F., Fritschy, J.-M., Lüthi, A., Kaupmann, K. and Bettler, B. (2004). Redistribution of GABAB(1) protein and atypical GABAB respones in GABAB(2)-deficient mice. J. Neurosci. 24, 6086-6097.

Schuler, V., Lüscher C., Blanchet, C, Klix, N., Sansig, G., Klebs, K., Schmutz, M,. Heid, J., Gentry, C., Urban, L., Fox, A., Spooren, W., Jaton, A.-L., Vigouret, J.-M., Pozza, M., Kelly, P.H., Mosbacher, J., Fröstl, W., Käslin, E., Korn, R., Bischoff, S., Kaupmann, K., Van der Putten, H. and Bettler, B. (2001). Epilepsy, hyperalgesia, impaired memory and loss of pre-and postsynaptic GABAB responses in mice lacking GABAB(1). Neuron 31, 47-58.

Kaupmann, K., Malitschek, B, Schuler, V., Heid, J., Froestl, W., Beck, P., Mosbacher, J., Bischoff, S., Kulik, A., Shigemoto, R., Karschin, A. and Bettler, B. (1998). GABAB receptor subtypes assemble into functional heteromeric complexes. Nature (London) 396, 683-687.

Mulle, C., Sailer, A., Pérez-Otaño, Dickinson-Anson, H., Castillo, P. E., Bureau, I., Maron, C., Gage, F. H., Mann, J., Bettler, B. and Heinemann, S. F. (1998). Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature (London) 392, 601-605.

Kaupmann, K., Huggel, H., Heid, J., Flor, P. J., Bischoff, S., Mickel, S. J., McMaster, G., Angst, C., Bittiger, H., Froestl, W. and Bettler, B. (1997). Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors. Nature (London) 386, 239-246Accompanying “News and Views” Article.