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Endothelial cells are essential to support the osteogenic potential of adipose-derived cells (Scherberich Lab)

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The in vivo bone formation capacity of human adipose-derived cells (A) (compact newly-formed bone tissue stained in dark green) is impaired by the depletion of T-cadherin-positive (endothelial) cells (B) but can be rescued by addition of generic, human umbilical vein endothelial cells (C). (Image: J. Guerrero et al., Stem Cells Transl Med, 2022)

The endothelial nature of T-cadherin-positive cells inside human adipose-derived cells have been demonstrated by the labs of Arnaud Scherberich and Ivan Martin. According to the researchers from the University of Basel and University Hospital Basel,  a crosstalk between stromal and T-cadherin-expressing (endothelial) cells in human adipose tissue critically regulates their osteogenic potential.

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