BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Sabre//Sabre VObject 4.5.8//EN CALSCALE:GREGORIAN BEGIN:VTIMEZONE TZID:Europe/Zurich X-LIC-LOCATION:Europe/Zurich TZURL:http://tzurl.org/zoneinfo/Europe/Zurich BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:19810329T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:19961027T030000 RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT UID:news1728@biomedizin.unibas.ch DTSTAMP;TZID=Europe/Zurich:20260430T104925 DTSTART;TZID=Europe/Zurich:20260505T140000 SUMMARY:Guest Speaker: Ivana Jaric\, PhD - Institute of Laboratory Animal S cience at the University of Zurich DESCRIPTION:Talk Summary:The historical exclusion of female subjects from p reclinical research is well documented\, and neuroscience has been among t he most resistant fields to change. For decades\, the assumption that ovar ian hormone fluctuations would introduce unwanted variability was used to justify male-only study designs\, leaving a critical gap in our understand ing of female brain physiology and its contribution to psychiatric disorde r risk\, one that remains largely unaddressed.In this talk\, Dr. Jaric wil l discuss how the ovarian reproductive cycle\, and its natural or pharmaco logical disruption\, drives changes in hippocampal molecular and structura l plasticity in ways that may underlie female-specific vulnerability to an xiety and depression. She will further demonstrate how accounting for\, or ignoring\, ovarian hormone status critically affects reproducibility\, ge neralizability\, and translational relevance in sex-inclusive study design s. Finally\, Dr. Jaric will outline strategies for including both sexes an d accounting for endocrine state in preclinical rodent neuroscience resear ch\, to bring preclinical research closer to clinical practice and improve health outcomes for everyone.Short bio: Dr. Ivana Jaric is a Group Leader at the Institute of Laboratory Animal Science\, University of Zurich. Her research has two main focuses: developing evidence-based guidelines to ma ke rodent studies that include both sexes more translationally relevant\, and investigating the epigenetic mechanisms underlying female-specific sus ceptibility to psychiatric disorders\, with a particular focus on the role of ovarian hormone status.  X-ALT-DESC:

Talk Summary:
The historical exclusion of female subjects from preclinical research is well documented\, and neur oscience has been among the most resistant fields to change. For decades\, the assumption that ovarian hormone fluctuations would introduce unwanted variability was used to justify male-only study designs\, leaving a criti cal gap in our understanding of female brain physiology and its contributi on to psychiatric disorder risk\, one that remains largely unaddressed.
In this talk\, Dr. Jaric will discuss how the ovarian reproductive cycl e\, and its natural or pharmacological disruption\, drives changes in hipp ocampal molecular and structural plasticity in ways that may underlie fema le-specific vulnerability to anxiety and depression. She will further demo nstrate how accounting for\, or ignoring\, ovarian hormone status critical ly affects reproducibility\, generalizability\, and translational relevanc e in sex-inclusive study designs. Finally\, Dr. Jaric will outline strateg ies for including both sexes and accounting for endocrine state in preclin ical rodent neuroscience research\, to bring preclinical research closer t o clinical practice and improve health outcomes for everyone.

< strong>Short bio: Dr. Ivana Jaric is a Group Leader at the Instit ute of Laboratory Animal Science\, University of Zurich. Her research has two main focuses: developing evidence-based guidelines to make rodent stud ies that include both sexes more translationally relevant\, and investigat ing the epigenetic mechanisms underlying female-specific susceptibility to psychiatric disorders\, with a particular focus on the role of ovarian ho rmone status.

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DTEND;TZID=Europe/Zurich:20260505T150000 END:VEVENT END:VCALENDAR