Carolyn King’s research group shows that specialized helper cells contribute to immunological memory


Spleen of a mouse with fluorescent antibodies. The yellow areas contain Tfh cells that are involved in maintaining immunological memory. (Image: University of Basel, Department of Biomedicine, Ludivine Litzler)

Marko Künzli, David Schreiner, and collaborators from Basel, Cambridge and the US demonstrated in a recent article published in Science Immunology that T follicular helper cells (Tfh) live much longer than previously thought and contribute to long-term immunity. This better understanding of Tfh cells opens up new prospects for creating long-term acquired immunity and developing improved vaccination strategies.