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Verdon Taylor and collaborators identified a signalling pathway that maintains neural stem cell quiescence in adult mouse brain

The image depicts Id4 (blue) and GFAP (black) expression in genetically labeled stem cells and their progeny (magenta) in the hippocampus of the mouse brain. The image presents an artistic coloration of the spatial and molecular factors in a niche. (Image: University of Basel)

In their study that was recently published in Cell Reports they discovered a central role fot the Notch2 effector Id4. Id4 not only blocks cell cycle entry but also promotes astrocytic differentiation of hippocampal neural stem cells.