Publications

Lodge M, Bischofberger J (2019) Synaptic properties of newly generated granule cells support sparse coding in the adult hippocampus. Behav Brain Res. 372: 112036.

Schulz JM, Knoflach F, Hernandez MC, Bischofberger J (2019) Enhanced Dendritic Inhibition and Impaired NMDAR Activation in a Mouse Model of Down Syndrome. J Neurosci. 39(26): 5210-21.

Schulz JM, Knoflach F, Hernandez MC, Bischofberger J (2018) Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors. Nature Communications 9:3576.

Normann C, Frase S, Haug V, von Wolff G, Clark K, Münzer P, Dorner A, Scholliers J, Horn M, Vo Van T, Seifert G, Serchov T, Biber K, Nissen C, Klugbauer N, Bischofberger J (2018) Antidepressants Rescue Stress-Induced Disruption of Synaptic Plasticity via Serotonin Transporter-Independent Inhibition of L-Type Calcium Channels. Biol Psychiatry. 84(1):55-64.

Li L, Sultan S, Heigele S, Schmidt-Salzmann C, Toni N, Bischofberger J (2017) Silent synapses generate sparse and orthogonal action potential firing in adult-born hippocampal granule cells. Elife. 6: e23612.

Fedele S, Collo G, Behr K, Bischofberger J, Müller S, Kunath T, Christensen K, Gündner AL, Graf M, Jagasia R, Taylor V (2017) Expansion of human midbrain floor plate  progenitors from induced pluripotent stem cells increases dopaminergic neuron differentiation potential. Sci Rep. 7(1):6036.

Iijima Y, Behr K, Iijima T, Biemans B, Bischofberger J, Scheiffele P (2016) Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure. Sci Rep. 6:27400.

Costa V, Aigner S, Vukcevic M, Sauter E, Behr K, Ebeling M, Dunkley T, Friedlein A, Zoffmann S, Meyer CA, Knoflach F, Lugert S, Patsch C, Fjeldskaar F, Chicha-Gaudimier L, Kiialainen A, Piraino P, Bedoucha M, Graf M, Jessberger S, Ghosh A, Bischofberger J, Jagasia R (2016) mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis. Cell Rep. 15(1):86-95.

Heigele S, Sultan S, Toni N, Bischofberger J (2016) Bidirectional GABAergic control of action potential firing in newborn hippocampal granule cells. Nat Neurosci. 19(2):263-270.

Sultan S, Li L, Moss J, Petrelli F, Cassé F, Gebara E, Lopatar J, Pfrieger FW, Bezzi P, Bischofberger J, Toni N (2015) Synaptic Integration of Adult-Born Hippocampal  Neurons Is Locally Controlled by Astrocytes. Neuron. 88(5):957-972.

Bolz L, Heigele S, Bischofberger J (2015) Running Improves Pattern Separation during Novel Object Recognition. Brain Plast. 1(1):129-141.

Oettinghaus B, Schulz JM, Restelli LM, Licci M, Savoia C, Schmidt A, Schmitt K, Grimm A, Morè L, Hench J, Tolnay M, Eckert A, D’Adamon P, Franken P, Ishihara N, Mihara K, Bischofberger J, Scorrano L, Frank S (2016) Synaptic dysfunction, memory deficitis and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons. Cell Death Differ. 23: 18-28.

Pohle J, Bischofberger J (2014) Supralinear dendritic Ca(2+) signalling in young developing CA1 pyramidal cells. J Physiol. 592(22):4931-4949.

Giachino C, Barz M, Tchorz JS, Tome M, Gassmann M, Bischofberger J, Bettler B, Taylor V (2014) GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors. Development. 141(1):83-90.

Schmidt-Salzmann C, Li L, Bischofberger J (2014) Functional properties of extrasynaptic AMPA and NMDA receptors during postnatal hippocampal neurogenesis. J Physiol. 592(1):125-140.

Lepski G, Jannes CE, Nikkhah G, Bischofberger J (2013) cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels. Front Cell Neurosci. 7:155.

Herpfer I, Hezel H, Reichardt W, Clark K, Geiger J, Gross CM, Heyer A, Neagu, V, Bhatia H, Atas HC, Fiebich BL, Bischofberger J, Haas CA, Lieb K, Normann C. (2012) Early life stress differentially modulates distinct forms of brain plasticity in young and adult mice. PLoS One 7:e46004.

Lepski G, Maciaczyk J, Jannes CE, Maciaczyk D, Bischofberger J, Nikkhah G. (2011) Delayed functional maturation of human neuronal progenitor cells in vitro. Mol Cell Neurosci, 47:36-44.

Schmidt-Hieber C, Bischofberger J (2010) Fast sodium channel gating supports localized and efficient axonal action potential initiation. J Neurosci, 30: 10233-10242.

Bucurenciu I, Bischofberger J, Jonas P (2010) A small number of open presynaptic Ca2+ channels triggers precisely timed transmitter release at a central GABAergic synapse. Nature Neuroscience 13:19-21.  

Niehusmann P, Seifert G, Clark K, Atas HC, Herpfer I, Fiebich B, Bischofberger J, Norman C (2010) Coincidence Detection and Stress Modulation of Spike Time-Dependent Long-Term Depression in the Hippocampus. J Neurosci 30:6225-6235. 

Lepski G, Jannes CE, Maciaczyk J, Papazoglou A, Mehlhorn AT, Kaiser S, Teixeira MJ, Marie SK, Bischofberger J, Nikkhah G (2010) Limited Ca2+ and PKA-pathway dependent neurogenic differentiation of human adult mesenchymal stem cells as compared to fetal neuronal stem cells. Exp Cell Res. 316:216-231.   

Babu H, Ramirez-Rodriguez G, Bischofberger J, Kempermann G (2009) Synaptic network activity induces neuronal differentiation of adult hippocampal precursor cells through BDNF signalling. Frontiers in Neuroscience 3:49.

Young C, Stegen M, Bernard R, Müller M, Bischofberger J, Veh RW, Haas CA, Wolfart J (2009) Upregulation of inward rectifier K+ (Kir2) channels in dentate gyrus granule cells in temporal lobe epilepsy. J Physiol 587:4213-4233.  

Stocca G, Schmidt-Hieber C, Bischofberger J (2008) Differential dendritic Ca2+ signalling in young and mature hippocampal granule cells. J Physiol 586: 3795-3811.

Schmidt-Hieber C, Jonas P, Bischofberger J (2008) Action potential initiation and propagation in hippocampal mossy fibre axons. J Physiol 586:1849-1857. 

Aponte Y, Bischofberger J, Jonas P (2008) Efficient Ca2+ buffering in fast spiking basket cells of rat hippocampus. J Physiol: 586: 2061-2075. 

Li Liyi, Bischofberger J, Jonas P (2007) Differential gating and recruitment of P/Q-, N-, and R-type Ca2+ channels in hippocampal mossy fiber boutons. J Neurosci 27: 13420-13429. 

Schmidt-Hieber C, Jonas P, Bischofberger J (2007) Subthreshold dendritic signal processing and coincidence detection in dentate gyrus granule cells. J Neurosci 27: 8430-8441

Gundlfinger A, Bischofberger J, Johenning FW, Torvinen M, Schmitz D, Breustedt J (2007) Adenosine modulates transmission at the hippocampal mossy fibre synapse via direct inhibition of presynaptic calcium channels. J Physiol (Lond) 582: 263-277.

Bischofberger J (2007) Young and excitable: New neurons in memory networks. Nature Neurosci, 10: 273-275.

Holderbach R, Clark K, Moreau J-L, Bischofberger J, Normann C (2007) Enhanced synaptic long-term depression in an animal model of depression. Biol Psychiatry 62: 92-100. 

Bischofberger J, Engel D, Liyi L, Geiger JR, Jonas P (2006) Patch-clamp recording from mossy fiber terminals in hippocampal slices. Nature Protocols 1: 2075-2081

Berkefeld H, Sailer CA, Bildl W, Thumfahrt J, Rhode V, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus H-G, Schulte U, Fakler B (2006) BKCa-Cav channel complexes as a mechanism of rapid and localized Ca2+-activated K+ signalling. Science 314: 615-620.

Couillard-Despres S, Winner B, Karl C, Lindemann G, Schmid P, Munding M, Aigner R, Wachs F, Laemke J, Kunz-Schughart L, Bogdahn U, Winkler J, Bischofberger J, Aigner L (2006) Targeted transgene expression in neuronal precursors: Watching young neurons in the old brain. Eur J Neurosci 24: 1535-1545.

Bischofberger J, Engel D, Frotscher M and Jonas P (2006) Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network. Pflugers Arch. 453: 361-372.

Song H, Kempermann G, Overstreet-Wadiche L, Zhao C, Schinder AF, Bischofberger J (2005) New neurons in the adult mammalian brain: Synaptogenesis and functional integration. J Neurosci 25:10366-10368.

Schmidt-Hieber C, Jonas P, Bischofberger J (2004) Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature 429: 184-187

Jonas P, Bischofberger J, Fricker D, Miles R (2004) Interneuron diversity series: Fast in, fast out – temporal and spatial signal processing in hippocampal interneurons. Trends Neurosci 27: 30-40

Bischofberger J, Geiger JRP, Jonas P (2002) Timing and efficacy of Ca2+ channel activation in hippocampal mossy fiber boutons. J Neurosci 22: 10593-10602.

Geiger JRP, Bischofberger J, Vida I, Fröbe U, Pfitzinger S, Weber HJ, Haverkampf K, Jonas P (2002) Patch-clamp recording in brain slices with improved slicer technology. Pflugers Arch. 443: 491-501.

Bischofberger J, Jonas P (2002) TwoB or not twoB: Differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus. Trends Neurosci 25: 600-603.

Jerecic J, Schulze CH, Jonas P, Sprengel R, Seeburg PH, Bischofberger J (2001) Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression. Mol Brain Research 94: 96-104.

Normann C, Peckys D, Schulze CH, Walden J, Jonas P, Bischofberger J (2000) Associative long-term depression in the hippocampus is dependent on postsynaptic N‑type Ca2+ channels. J Neurosci 20: 8290-8297.

Jonas P, Bischofberger J, Sandkühler J (1998) Co-release of two fast neurotransmitters at a central synapse. Science 281: 419-424.

Bischofberger J, Jonas P (1997) Action potential propagation into the presynaptic dendrites of rat mitral cells. J Physiol (Lond) 504: 359-365.

Bischofberger J, Schild D (1996) Glutamate and N-acetyl-aspartyl-glutamate block HVA calcium currents in frog olfactory bulb interneurones via an mGluR2-like receptor. J Neurophysiol 76: 2089-2092.

Schild D, Geiling H, Bischofberger J (1995) Imaging of L-type Ca2+ channels in olfactory bulb neurones using fluorescent dihydropyridine and a styryl dye. J Neurosci Meth 59: 183-190.

Bischofberger J, Schild D (1995) Different spatial patterns of [Ca2+] increase caused by N- and L-type Ca2+ channel activation in frog olfactory bulb neurones. J Physiol (Lond) 487: 305-317.

Schild D, Bischofberger J (1991) Ca2+ modulates an unspecific cation conductance in olfactory cilia of Xenopus laevis. Exp Brain Res 84: 187-194.