Publications

Werthmann, R.C., Tzouros, M., Lamerz, J., Augustin, A., Fritzius, T., Trovo, L., Stawarski, M., Raveh, A., Diener, C., Fischer, C., Gassmann, M., Lindemann, L. and Bettler, B. Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1/5 receptors. Neuropharmacology, pre-proof.

Rosenbaum, M.I., Clemmensen, L.S. Bredt, D.S., Bettler, B., Strømgaard, K. (2020). Targeting receptor complexes: A new dimension in drug discovery. Nat. Rev. Drug Discov. 19 (12), 884-901.

Fritzius T., Stawarski M., Isogai S., Bettler B. (2020). Structural Basis of GABAB Receptor Regulation and Signaling. Current Topics in Behavioral Neurosciences. Springer, Berlin, Heidelberg. doi.org/10.1007/7854_2020_147.

Bhandari, P. Vandael, D., Fernàndez-Fernàndez, D., Fritzius, T., Kleindienst, D., Montanaro, J., Gassmann, M., Jonas, P. Kulik, A., Bettler, B., Shigemoto, R., Koppensteiner, P. (2020). GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals. bioRxiv, doi:10.1101/2020.04.16.045112.

Alexander, S.P., Christopoulus, A., Davenport, A.P., Kelly, E., Mathie, A., Peters, J.A., Veale, E.L., Armstrong, J.F., Faccenda, E., Harding, S.D., Pawson, A.J., Sharman, J.L., Southan, C., Davies, J.A. and CGTP Collaborators. (2019). The concise guide to pharmacology 2019/20: G-protein-coupled receptors. Br. J. Phamacol. 176 (S1), 21-141.

Martin-Belmonte, A., Aguado, C., Alfaro-Ruiz, R., Moreno-Martinez, A.E., De la Ossa, L., Martinez-Hernández, J., Buisson, A., Früh, S., Bettler, B., Shigemoto R., Fukazawa, Y. and Luján, R. (2020). Reduction in the neuronal surface of post- and pre-synaptic GABAB receptors in the hippocampus in a mouse model of Alzheimer's disease. Brain Pathology 30, 554-575.

Tsunekawa, T., Banno, R., Yaginuma, H., Taki, K., Mizoguchi, A., Sugiyama, M., Onone, T., Takagi, H., Hagiwara, D., Ito, Y., Iwama, S., Goto, M., Suga, H., Bettler, B., Arima, H. (2019). GABAB receptor signaling in the mesolimbic system suppresses binge-like consumption of a high fat diet. iScience 20, 337-347.

Winkler, M., Biswas, S., Berger, S.M., Küchler, M., Enkel, T., Preisendörfer, L., Choo, M., Früh, S., Rem, P.D., Enkel, T., Arnold, B.,  Komljenovic, D., Sticht, C., Goerd, S., Bettler. B., von Bohlen und Halbach, O., Bartsch, D.,  and Géraud, C. (2019). Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autismlike behavior. Mol. Psychiatry 25, 2979-2993.

Sereikaitė, V., Fritzius, T., Kasaragod, V.B., Bader, N., Maric, H., Schindelin, H., Bettler. B.and Strømgaard, K. (2019). Targeting the γ-aminobutyric acid type B (GABAB) receptor complex: Development of inhibitors targeting the K+ channel tetramerization domain (KCTD) containing proteins/GABAB receptor protein-protein interaction.  J. Med. Chem. 62, 8819-8830.

Di Giorgio N.P., Bizzozzero H.M., Surkin P.N., López P.V., Bourguignon N.S., Dorfman V.B., Bettler B., Libertun C., and Lux-Lantos V. (2019). Multiple failures in the lutenising hormone surge generating system in GABAB1 KO female mice. J. Neuroendocrinol. 31 (e12765).

Fritzius, T., Bettler. B. (2019). The organizing principle of GABAB receptor complexes: Physiological and pharmacological implications. BCPT Basic & Clinical Pharmacology & Toxicology doi:org/10.1111/bcpt:13241.

Dinamarca, M.C., Raveh, A., Schneider, A., Rem, P.D., Stawarski, M., Früh, S., Fritzius, T., Lalanne, T., Turecek, R., Choo, M., Besseyrias, V., Bildl, W., Bentrop, D., Staufenbiel, M., Gassmann, M., Fakler, B., Schwenk, J. and Bettler B. (2019). Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing. Nature Commun. 10 (1331):1-17.

Pedrón, A., Varani, A.P., Bettler, B., and Balerio, G.N. (2019). GABAB receptors modulate morphine antinociception: Pharmacological and genetic approaches. Pharmacol. Biochem. Behav. 180: 11-21.

Tome, M., Tchorz, J., Gassmann, M., Bettler, B. (2019). Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1. Stem Cell Research, 38 (101390):1-9.

Vickers, E.D., Clark, C., Osypenko, D., Fratzl, A, Kochubey, O., Bettler, B., and Schneggenbruger, R. (2018). Parvalbumin-interneuron output synapses show spike-timing dependent plasticity that contributes to auditory map remodeling. Neuron 99, 720-735.

Bettler, B., Crunelli, V., Enna, S.J.A tribute to Norman G Bowery (2018). Neuropharmacology136, 1-2.

Luján R., Aguado C., Ciruela F., Cózar J., Kleindienst D., de la Ossa L., Bettler, B., Wickman K., Watanabe M., Shigemoto R. and Fukazawa Y. (2018). Differential association of GABAB receptors with their effector ion channels in Purkinje cells. Brain Struct. Funct. 223(3), 1565-1587.

Ulrich, D., Lalanne, T., Gassmann, M., and Bettler, B. (2018). GABAB receptor subtypes differentially regulate thalamic spindle oscillations. Neuropharmacology 136, 106-116.

Porcu A., Melis M., Turecek R., Ullrich C., Mocci I., Bettler, B., Gessa G.L., and Castelli M.P. (2018). Rimonabant, a potent CB1 cannabinoid receptor antagonist, is a Gαi/o protein inhibitor. Neuropharmacology 133, 107-120.

Mariotti, L., Losi, G., Gomez-Gonzalo, M., Melone, M., Chiavegato, A., Lia, A., Sessolo, M., Bovetti, S., Forli, A., Zonta, M., Requie, L.M., Marcon, I., Pugliese, A., Viollet, C., Bettler, B., Fellin, T., Conti F., and Carmignoto G.(2018). Interneuron-specific signalling unveils unique somatostatin-mediated properties of astrocytes in adult neocortex. Nature Commun. 9(82), 1-14.

Alexander S.P., Kelly E., Marrion N.V., Peters J.A., Faccenda E., Harding S.D., Pawson A.J., Sharman J.L., Southan C., Buneman O.P., Cidlowski J.A., Christopoulos A., Davenport A.P., Fabbro D., Spedding M., Striessnig J., Davies J.A. and CGTP Collaborators. (2017). The concise guide to pharmacology 2017/2018: Overview. Br J Pharmacol. 174 Suppl 1:S1-S16.

Varani, A.P., Pedron, V.T., Aon, A.J., Höcht, C., Acosta, G.B., Bettler, B., and Balerio, G.N. (2017). Nicotine-induced alterations are modulated by GABAB receptor activity. Addiction Biology 23, 230-246.

Edwards, N.J., Zhang, S., McDevitt, R.A., Tejeda, H.A., Pignatelli, M., Bass, C.E., Bettler, B., Morales, M., and Bonci, A. (2017) Circuit specificity in the inhibitory architecture of the VTA regulates behavioral reponses to cocaine. Nature Neurosci. 20, 438-448.

Jacobson, L.H., Hoyer, D., Fehlmann, D., Bettler, B., Kaupmann, K., and Cryan, J.F. (2017) Blunted 5-HT1A receptor mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms. Psychopharmacol. 234, 1511–1523.

Zapata, J., Moretto, E., Hamman, S, Murru, L., Longatti, A., Mazza, D., Benedetti, L., Fossatai, M., Heise, C., Ponzoni, L., Valnegrti, P., Braida, D., Sala, M. Francolini, M., Hildebrand, J., Kalscheuer, V., Fanellim F., Sala, C., Bettler, B., Bassani, S., Smart. T.G., and Passafaro, M. (2017) Epilepsy- and intellectual disability-linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission. Nature Commun. 8, 14536.

Fritzius, T., Turecek, R., Seddik, R., Kobayashi, H., Tiao, J., Rem, P.D., Metz, M., Kralikova, M., Bouvier, M., Gassmann, M., and Bettler, B. (2017) KCTD hetero-oligomers confer unique kinetic properties on hippocampal GABAB receptor-induced K+-currents. J. Neurosci. 37(5), 1162-1175.

Cathomas, F., Sigrist, H., Schmid, L., Seifritz, E., Gassmann, M., Bettler, B.,* and Pryce, C.R.* (2017) Behavioural endophenotypes in mice lacking the auxiliary GABAB receptor subunit KCTD16. Behav. Brain Res. 317, 393-400. *Corresponding authors.

Booker, S. A., Althof, D., Gross, A., Loreth, D., Müller, J., Unger, A., Fakler, B., Varro, A., Watanabe, M., Gassmann, M., Bettler, B., Shigemoto, R., Imre Vida,I., and Kulik, Á. (2017). KCTD12 auxiliary proteins modulate kinetics of GABAB receptor-mediated inhibition in cholecystokinin-containing interneurons. Cerebral Cortex, 27 (3), 2318–2334.

Perea, G., Gómez, R., Mederos, S., Covelo, A., Ballestros, J., Schlosser, L., Hernández-Vivanco, A., Rayan, A., Martín-Fernández, M., Quintana, R., Rayan, A., Díez, A., Fuenzalida, M., Agarwal, A., Bergles, D., Bettler, B., Manahan-Vaughan, D., Martín, E.D., Kirchhoff, F., and Araque A. (2016) Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks. eLife 5, e20362.

Sailer, M.H.M., Sarvepalli, D., Brégère, C., Fisch, U., Guentchev, M., Weller, M., Guzman, R., Bettler, B., Ghosh, A., and Hutter, G. (2016). An enzyme- and serum-free neural stem cell culture model for EMT investigation suited for drug discovery. J. Vis. Exp. 114, e54018, 1-16.

Zhang, J., Tan, L., Ren, Y., Liang, J., Lin, R., Feng, Q., Zhou, J., Hu, F., Ren, J., Wei, C., Yu, T., Zhuang, Y., Bettler, B., Wang, F. and Luo, M. (2016). Presynaptic excitation via GABAB receptors in habenual cholinergic neurons regulates fear memory expression. Cell 166, 716-728.

Jurado-Parras, M.T., Delgado-García, J.M., Sánchez-Campusano, R., Gassmann, M., Bettler, B.,* and Gruart, A.* (2016). Presynaptic GABAB receptors regulate hippocampal synapses during associative learning in behaving mice. PLoS ONE 11(2), e0148800. *Corresponding authors.

Schwenk, J.*, Pérez-Garci, E.*, Schneider, A., Kollewe, A., Gauthier-Kemper, A., Fritzius, T., Raveh, A., Dinamarca, M.C. Hanuschkin, A., Bildl, W., Klingauf, J., Gassmann, M., Schulte, U., Bettler, B.#, and Fakler, B.# (2016). Modular composition and dynamics of native GABAB receptor complexes identified by high-resolution proteomics. Nature Neurosci. 19(2), 233-42. *Co-first author, #Corresponding authors.

Harmeier, A., Obermueller, S., Meyer, C.A., Revel, F., Buchy, D., Chaboz, S., Dernick, G., Wettstein, J.G., Rolink, A., Bettler, B., and Hoener M.C. (2016). Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers. European Neuropsychopharmacol. 25(11), 2049-2061.

Jacobson, L.H., Sweeney, F.F., Kaupmann, K., O'Leary, O.F. Gassmann; M., Bettler, B., and Cryan J.F. (2016). Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine. Behav. Brain Res. 298, 12-16.

Doly, S., Shirvani, H., Gäta, G., Meye, F.J., Emerit, M.-B., Enslen, H., Achour, L., Pardo-Lopez, L., Yang, S.-K., Armand, V., Gardette, R., Giros, B., Gassmann, M., Bettler, B., Maeli, M., Darmon, M, and Marullo, S. (2016). GABAB receptor cell surface export is controlled by an endoplamic reticulum gatekeeper. Mol. Psychiatry 21(4), 480-490.

Giachino, C., Boulay, J.-L., Ivanek, R., Alvarado, A., Tostado, C., Lugert, S., Tchorz, J., Coban, M., Mariani, L., Bettler, B., Lathia, J., Frank, S., Pfister, S., Kool, M., and Taylor, V. (2015). A tumor suppressor function for Notch signaling in specific forebrain tumor types. Cancer Cell 28(16), 730-742.

Vertkin, I., Styr, B., Slomowitz, E., Ofir, N., Shapira, I., Berner, D., Fedorova, T., Laviv, T., Barak-Broner, N., Greitzer-Antes, D., Gassmann, M., Bettler, B., Lotan, I., and Slutzky, I. (2015). GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks. Proc. Natl. Acad. Sci. USA 112(25), E3291-3299.

Takahashi, A., Lee, R., Iwasato, T., Itohara, S., Arima, H., Bettler, B., Miczek, K., and Koide, T. (2015). Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. J. Neurosci. 35(16), 6452-6463.

Hanack, C., Moroni, M., Lima, W.C., Wende, H., Kirchner, M., Adelfinger, L., Schrenk-Siemens, K., Tappe-Theodor, A., Wetzel, C., Kuich, H., Gassmann, M., Roggenkamp, D., Bettler, B., Lewin, G.R., Selbach., M. and Siemens, J. (2015). GABA blocks pathological but not acute TRPV1 pain signals. Cell 160(4), 759-770.

Cathomas, F., Stegen, M., Sigrist, H., Schmid, L., Seifritz, E., Gassmann, M., Bettler, B.*, Pryce, C.R.* (2015). Altered emotionality, circadian rhythmicity and neuronal excitability in mice lacking KCTD12, an auxiliary subunit of GABAB receptors associated with mood disorders. Transl. Psychiatry 5, e510. * Corresponding authors.

Rajalu, M., Fritzius, T., Adelfinger, L., Jacquier, V., Besseyrias, V., Gassmann, M., Bettler, B. (2015). Pharmacological characterization of GABAB receptor subtypes assembled with auxiliary KCTD subunits. Neuropharmacology 88, 145-154.

Varani, A.P., Pedrón, V.T., Machado, L.M., Antonelli, M.C., Bettler, B., Balerio, G.N. (2015). Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal. Neuropharmacology 90, 90-101.

Martin C.B., Gassmann, M., Chevarin C., Hamon, M., Rudolph, U., Bettler, B., Lanfumey, L, Mongeau, R. (2014). Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress. J. Neurochem. 131(5), 566-572.

O'Leary, O.F., Felice, D., Galimberti, S., Savignac, H.,M., Bravo, J.A., Crowley, T., El Yacoubi, M., Vaugeois, J., Gassmann, M., Bettler, B., Dinan, T.G., Cryan, J.F. (2014).
GABAB(1) receptor subunit isoforms differentially regulate stress resilience. Proc. Natl. Acad. Sci. USA 111(42), 15232-15237.

Adelfinger, L., Turecek, R., Ivankova, K., Jensen, A.A., Moss, S.J., Gassmann, M., Bettler, B. (2014). GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization. Biochemical Pharmacology 91, 369-379.

Turecek, R., Schwenk, J., Fritzius, T., Ivankova, K., Zolles, G., Adelfinger, L., Jacquier, V., Besseyrias, V., Gassmann, M., Schulte, U., Fakler, B., Bettler, B. (2014). Auxiliary GABAB receptor subunits uncouple G-protein βγ subunits from effector channels to induce desensitization. Neuron 82, 1032-1044.

Varani, A., Pedrón, V.T., Bettler, B., Balerio, G.C. (2014). Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: Genetic and pharmacological approaches. Neuropharmacology 81, 31-41.

Di Giorgio, N.P., Semaan, S.J., López, P.V., Bettler, B., Libertun, C., Lux-Lantos, V.A. and Kauffman, A.S. (2014). Impaired GABAB receptor signaling dramatically upregulates Kiss1 expression selectively in non-hypothalamic brain regions of adult but not prepubertal mice. Endocrinology 155(3), 1033-1044.

Faroni, A., Castelnovo, L., Procacci, P., Caffino, L., Fumagalli, F., Melfi, S., Gambarotta, G., Bettler, B., Wrabetz, L. and Magnaghi, V. (2014). Deletion of GABAB receptors in Schwann Cells regulates remak bundles and small nociceptive C-fibers. Glia 62, 548-565.

Giachino, C., Barz, M., Tchorz, JS., Tome, M., Gassmann, M., Bischofberger, J., Bettler, B. and Taylor, V. (2014). GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors. Development 141(1), 83-90.

Ito, Y., Banno, R., Shibata, M., Adachi,K., Hagimoto, S., Hagiwara, D., Ozawa, Y., Goto, M., Suga,H., Sugimura, Y., Bettler, B., Oiso, Y., and Arima, H. (2013). GABA type-B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance and hypothalamic inflammation in male mice on a high fat diet. J. Neurosci. 33(43), 17166-73.

Di Giorgio, NP., Catalano, PN., López, PV., González, B., Semaan, SJ., López GC., Kauffman, AS., Rulli, SB., Somoza, GM., Bettler, B., Libertun C., Lux-Lantos, VA. (2013). Lack of functional GABAB receptors alters Kiss1, Gnrh1 and Gad1 mRNA expression in the medial basal hypothalamus at postnatal day 4. Neuroendocrinology Vol. 98, No. 3.

Wedemeyer, C., Zorilla de San Martin, J., Ballestero, J., Gómez-Casati, ME., Torbidoni, AV., Fuchs, PA., Bettler, B., Elgoyhen, AB., Katz, E. (2013). Activation of Presynaptic GABAB(1a, 2) receptors inhibits synaptic transmission at mammalian inhibitory cholinergic olivocochlear-hair cell synapses. J. Neurosci. 33(39), 15477-15487.

Ivankova, K., Turecek, R., Fritzius, T., Seddik, R., Prezeau, L., Comps-Agrar, L., Pin, JP., Fakler, B., Besseyrias, V., Gassmann, M., Bettler, B. (2013). Up-regulation of GABAB receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12). J.Biol.Chem. 288 (34), 24848-56.

Crivello, M., Bonaventura, M.M., Chamson-Reig, A., Arany, E., Bettler, B., Libertun, C,., Lux-Lantos, V.A. (2013). Postnatal development of the endocrine pancreas in mice lacking functional GABAB receptors. Am J. Physiol Endocrinol Metab. 304 (10), E1064-76.

Booker, S.A., Gross, A., Althof, D., Shigemoto, R., Bettler, B., Frotscher, M., Hearing, M., Wickman, K., Watanabe, M., Kulik, A., Vida, I. (2013). Differential GABAB-Receptors-Mediated Effects in Perisomatic- and Dendrite-Targeting Parvalbumin Interneurons. J. Neurosci. 33(18), 7961-7974.

Craig, M. T., Mayne, E. W., Bettler, B., Paulsen, O., McBain,. C. J. (2013). Distinct roles of GABAB1a- and GABAB1b-containing GABAB receptors in spontaneous and evoked termination of persistent cortical activity. J. Physiol. 591, 835-843.

Foster, J. D., Kitchen, I., Bettler, B., Chen, Y. (2013). GABAB receptor subtypes differentially modulate synaptic inhibition in the dentate gyrus to enhance granule cell output. Br. J. Pharmacol. 168, 1808-1819.

Bonaventura M.M., Rodriguez, D., Ferreira, M.L., Crivello, M., Repetto, E.M., Bettler, B., Libertun, C., Lux-Lantos, V.A. Sex differences in insulin resistance in GABAB1 knockout mice. (2013). Life Sciences 92, 175–182.

Dill, M.T., Tornillo, L., Fritzius, T., Terracciano, L., Semela, D., Bettler, B., Heim M.H., Tchorz, J.S. (2013). Constitutive Notch2 signaling induces hepatic tumors in mice. Hepatology 57(4), 1607-1619.

Seddik, R., Jungblut, S.P., Silander, O.K., Rajalu, M., Fritzius, T., Besseyrias, V., Jacquier, V., Fakler, B., Gassmann, M., Bettler B. (2012). Opposite effects of KCTD subunit domains on GABAB receptor-mediated desensitization. J. Biol. Chem. 287(47), 39869-77.

Yang, J., Bücker, S., Jungblut, B., Böttger, T., Cinnamon, Y., Tchorz, J., Müller, M., Bettler, B., Harvey, R., Sun, Q.-Y., Schneider, A. Braun. T. (2012). Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart. Cardiovasc. Res. 96, 276-285.

Zecharia, A.Y. Yu, X., Götz, T., Ye, Z., Carr, D.R., Wulff, P., Bettler, B., Vyssotski, A.L. Brickley, S.G., Franks, N.P., Wisden, W. (2012). GABABergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J. Neurosci. 32(38), 13062-13075.

Varani, A.P., Machado, L.M., Bettler, B., Balerio, G.N. (2012). Acute behavioural responses to nicotine and nicotine withdrawal syndrome are modified in GABAB1 knockout mice. Neuropharmacology 63, 863–872.

Tchorz, J.S., Cloëtta, D., Tome, M., Sivasankaran, B., Grzmil, M., Huber, R.M., Rutz-Schatzmann, F., Kirchhoff, F., Schaeren-Wiemers, N., Gassmann, M., Hemmings, B.A., Merlo, A., Bettler, B. (2012). Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry. Cell Death & Disease e325, 1-9.

Moloney, R.D., O’Leary O.F., Felice D., Bettler, B., Dinan, T.G., Cryan J.F. (2012). Early-life stress in mice induces visceral hypersensitivity in mice. Neuroscience Letters 512, 99-102.

Tchorz, J.S., Suply, T., Ksiak, I., Giachino, C., Cloetaa, D., Danzer,C.P., Doll, T., Isken, A., Lemaistre, M., Taylor., V. Bettler, B., Kinzel., B. Müller M. (2012). A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters. PLoS ONE 7(1), e30011, 1-12.

Laviv, T., Vertkin, I., Berdichevsky, Fogel, H., Y., Riven, I., Bettler, B., Slesinger, P. A. and Slutsky, I. (2011). Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses. J. Neurosci. 31(35), 12523-12532.

Metz, M., Gassmann, M., Fakler, B., Schaeren-Wiemers, N. and Bettler, B. (2011). Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b and 16 in the mouse brain. J. Comp. Neurol. 519(8), 1435-1454.

Comps-Agrar, L., Kniazeff, J., Norskov-Lauritsen, L., Maurel, D., Gassmann, M, Gregor, N., Prezeau, L., Bettler, B., Durroux, T., Trinquet, E and J.-P. Pin. (2011). The oligomeric state sets GABAB receptor signaling efficacy. EMBO J. 30(12), 2336-2349.

Revel, F. G., Moreau, J.-L., Gainetdinov, R. R., Bradaia, A., Sotnikova, T. D., Mory, R., Durkin, S., Groebke-Zbinden, K., Norcross, R. D., Meyer, C. A., Metzler, V., Chaboz, S., Ozmen, L., Trube, G., Pouzet, B., Bettler , B., Caron, M. G., Wettstein, J. G. and Hoener, M. C. (2011). TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc. Natl. Acad. Sci. USA 108(20), 8485–8490.

Maurice, P., Daulat, A.M, Turecek, R., Ivankova-Susankova, K., Zamponi, F., Kamal, M., Clement, N., Guillaume, J.-L., Bettler, B., Gales, C., Delagrange, P. and Jockers, R. (2010). Molecular organization and dynamics of the melatonin MT1 receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and Gi coupling. EMBO J. 29, 3646-3659.

Vienne, J., Bettler, B., Franken, P. and Tafti, M. (2010). Differential effects of GABAB receptor subtypes, γ-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulation. J. Neurosci. 30(42), 14194-14204.

Guetg, N., Abdel Aziz, S., Holbro, N., Turecek R., Rose, T., Seddik, R., Gassmann, M., Moes, S., Jenoe, P, Oertner, T.G., Casanova, E. and Bettler, B. (2010). NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1. Proc. Natl. Acad. Sci. USA 107(31), 13924-13929.

Schwenk, J., Metz, M., Zolles, G., Turecek, R., Fritzius, T., Bildl, W., Tarusawa, E., Kulik, A., Unger, A., Ivankova, K., Seddik, R., Tiao, J.Y., Rajalu, M., Trojanova, J., Rohde V., Gassmann, M., Schulte, U., Fakler, B. and Bettler, B. (2010). Native GABAB receptors are heteromultimers with a family of auxiliary subunits. Nature 465(7295), 231-235. Highlights in Sci. Signal. 3, ec148 (2010); Nat. Struct. Mol. Biol. 17(5), 546 ( 2010).

Catalano, P.N., Di Giorgio, N., Bonaventura, M., Bettler, B., Libertun, C., and Lux-Lantos, V.A. (2010). Lack of functional GABAB receptors alters GnRH physiology and sexual dimorphic expression of GnRH and GAD-67 in the brain. Am J Physiol Endocrinol Metab. 298(3), E683-96.

Biermann, B., Ivankova-Susankova, K., Bradaia, A., Abdel Aziz, S., Besseyrias, V., Kapfhammer, J.P., Missler, M., Gassmann, M. and Bettler, B. (2010). The sushi domains of GABAB receptors function as axonal targeting signals. J. Neurosci. 30(4), 1385-1394.

Gangadharan, V., Agarwal, N., Brugger, S., Tegeder, I. Bettler, B., Kuner R., and Kurejova, M. (2009). Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo. Mol. Pain 5(68), 1-12.

Bradaia, A., Trube, G., Stalder, H., Norcross, R.D., Ozmen, L., Wettstein, J.G., Pinard A., Buchy D., Gassmann, M., Hoener, M.C. and Bettler, B. (2009). The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc. Natl. Acad. Sci. USA 106(47), 20081-20086.

Fernández-Alacid, L., Aguado, C., Ciruela, F., Martín R., Colón J., Cabañero, M. J. Gassmann, M., Watanabe, M., Shigemoto, R., Wickman, K., Bettler, B., Sánchez-Prieto, J. and Luján, R. (2009). Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. J. Neurochem. 110(4), 1363–1376.

Casanova, E., Guetg, N., Vigot, R., Seddik, R., Julio-Pieper, M., Hyland, N.P., Cryan, J.F., Gassmann, M., and Bettler, B. (2009). A mouse model for visualization of GABAB receptors. Genesis 47(9), 595-602.

Tchorz, J.S., Kinter J., Müller, M., Tornillo, L., Heim, M.H. and Bettler, B. (2009). Notch2 signalingpromotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice. Hepatology 50(3), 871-879.

Guetg, N., Seddik, R., Vigot, R., Turecek, R., Gassmann, M., Vogt, K., Bräuner-Osborne, H., Shigemoto, R., Kretz, O., Frotscher, M., Kulik, A., and Bettler, B. (2009). The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses. J. Neurosci. 29(5), 1414-1423.

Wellendorph, P., Johansen, L.D., Jensen, A.A., Casanova, E., Gassmann, M., Deprez, P., Clément-Lacroix, P., Bettler, B., and Bräuner-Osborne H. (2009). No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. J. Mol. Endocrinol. 42, 215-223.

Matsuki, T., Nomiyama, M., Takahira, H., Hirashima, N., Kunita, S., Takahashi, S., Yagami, K., Kilduff, T.S., Bettler, B., Yanagisawa, M., and Sakurai, T. (2009). Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc. Natl. Acad. Sci. USA 106(11), 4459-4464. Highlight in Cell 137(3), 389 (2009).

Maison, S.F., Casanova, E., Holstein, G.R., Bettler, B., and Liberman, M.C. (2009). Loss of GABAB receptors in cochlear neurons: Threshold elevation suggests modulation of outer hair cell function by type-II afferent fibers. J. Assoc. Res. Otolaryngol. 10, 50-63.

Tiao, J.Y., Bradaia, A., Biermann, B., Kaupmann, K., Metz, M., Haller, C., Rolink, A.G., Pless, E., Barlow, P.N. Gassmann, M. andBettler, B. (2008). The sushi domains of secreted GABAB1 isoforms selectively impair GABAB heteroreceptor function. J. Biol. Chem. 283(45), 31005-31011.

Magnaghi, V., Ballabio, M., Camozzi, F., Colleoni, M., Consoli, A., Gassmann, M., Lauria, G., Motta, M., Procacci, P., Trovato, A.E., and Bettler, B. (2008). Altered peripheral myelination in mice lacking GABAB receptors. Mol. Cell. Neurosci. 37, 599-609.

Lindemann, L., Meyer, C.A., Jeanneau, K., Bradaia, A., Ozmen, L., Bluethmann, H., Bettler, B., Wettstein, J.G. Borroni, E., Moreau, J.-L. and Hoener, M.C. (2008). Trace amine-associated receptor 1 modulates dopaminergic activity J. Pharmacol. Exp. Ther. 324, 948–956.

Bonaventura, M., Catalano, P.N., Chamson-Reig, A., Aranay, E., Hill, D.,Bettler, B., Saravia, F., Libertun, C., and Lux-Lantos, V.A. (2008). GABAB receptors and glucose homeostasis: Evaluation in GABAB receptor knockout mice. Am. J. Physiol. Endocrinol. Metab. 294, E157-E167.

Ulrich, D., Besseyrias, V. and Bettler, B. (2007). Functional mapping of GABAB -receptor subtypes in the thalamus. J. Neurophysiol. 98, 3791–3795.

Cheng, Z., Tu, C., Rodriguez, L., Chen, T.H. Dvorak, M.M., Margeta, M., Gassmann, M., Bettler, B., Shoback, D. and Chang, W. (2007). Type Bgamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes. Endocrinology 148(10), 4984–4992.

Chang, W., Tu, C., Cheng, Z., Rodriguez, Chen, T.-H., Gassman, M., Bettler, B., Margeta, M., Jan, L.Y., and Shoback, D. (2007). Complex formation with the type B γ-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. J. Biol. Chem. 282(34), 25030-25040.

Pinheiro, P.S., Perrais, D., Coussen, F., Barhanin, J., Bettler, B., Mann, J.R., Malva, J.O., Heinemann, S.F. and Mulle, C. (2007). GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proc. Natl. Acad. Sci. USA 104(29), 12181-12186.

Ksiazek, I., Burkhardt, C., Lin, S., Seddik, R., Maj, M., Bezakova, G., Jucker, M., Arber, S., Caroni, P., Sanes, J.R., Bettler, B. and Ruegg, M.A. (2007). Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death. J. Neurosci. 27(27),7183–7195.

Jacobson, L.H., Kelly, P.H, Bettler, B., Kaupmann K. and Cryan, J.F. (2007). Specific roles of GABAB1 receptor isoforms in cognition. Behavioural Brain Research 181, 158-162.

Jacobson, L.H., Bettler, B., Kaupmann, K. and Cryan, J.F. (2007). Behavioural evaluation of mice deficient in GABAB(1) receptor isoforms in tests of unconditioned anxiety. Psychopharmacology 190, 541-553.

Jacobson, L.H., Bettler, B., Kaupmann, K. and Cryan J.F. (2006). GABAB(1) receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.J. Pharmacol. Exp. Ther. 319(3), 1317-1326.

Vigot, R., Barbieri, S., Bräuner-Osborne, H., Turecek, R., Shigemoto, R., Zhang, Y.-P., Luján, R., Jacobson, L.H., Biermann, B., Fritschy, J.-M., Vacher, C.-M., Müller, M., Sansig, G., Guetg, N., Cryan, J.F., Kaupmann, K., Gassmann, M., Oertner, T.G. and Bettler, B. (2006). Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron 50(4), 589-601. Highlights in Neuron 50(4), 521-524 (2006); Nature 44, 387, (2006); Nature Reviews 7, 506, (2006).

Pérez-Garci, E., Gassmann, M., Bettler, B. and Larkum. M. E. (2006). The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons. Neuron 50(4), 603-16.

Shaban, H., Humeau, Y., Herry, C., Cassasus, G., Shigemoto, R., Ciocchi, S., Barbieri, S. van der Putten, H., Kaupmann, K., Bettler, B. and Lüthi A. (2006). Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nature Neurosci. 9(8), 1028-1035.

Jacobson, L.H., Kelly, P.H., Bettler, B., Kaupmann, K. and Cryan J.F. (2006). GABAB1 receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories. J. Neurosci. 26(34), 8800-8803.

Vacher, C.-M., Gassmann, M., Desrayaud, S., Challet E., Bradaia, A., Hoyer, D., Waldmeier, P., Kaupmann, K., Pévet, P. andBettler, B. (2006). Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice. J. Neurochem. 97, 979-991.

Kulik, A., Vida, I., Fukazawa, Y., Guetg, N., Kasugai, Y., Marker, C.L., Rigato, F., Bettler, B., Wickman, K., Frotscher, M. and Shigemoto, R. (2006). Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells. J. Neurosci., 26(16), 4289-4297.

Engle, M.P., Gassmann, M., Sykes K.T., Bettler, B. and Hammond, D.L. (2006). Spinal nerve ligation does not alter the expression or function of GABAB receptors in spinal cord and dorsal root ganglia of the rat. Neuroscience 138 (4), 1277-1287.

Rey-Roldán, E.B., Bianchi, M.S., Bettler, B., Becu-Villalobos, D., Lux-Lantos, V.A. Libertun, C. (2006). Adenohypophyseal and hypothalamic GABAB receptor subunits are downregulated by estradiol in adult female rats. Life Sci. 79, 342-350.

Catalano, P.N., Bonaventura, M.M., Silveyra P., Bettler, B., Libertun C. and Lux-Lantos, V.A. (2005). GABAB1 knockout mice reveal alterations in prolactin levels, gonadotropic axis, and reproductive function. Neuroendocrinology 82, 294-305.

Sauter, K., Grampp, T., Fritschy J.-M., Kaupmann, K., Bettler, B., Mohler, H., Benke, D. (2005). Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABAB receptors. J. Biol. Chem. 280, 33566-33572.

Bianchi, M.S., Lux-Lantos, V.A., Bettler, B. and Libertun, C. (2005). Expression of γ-aminobutyric acid-B receptor subunits in hypothalamus of male and female developing rats. Dev Brain Res. 160, 124-129.

Gassmann, M., Haller, C., Stoll, Y., Aziz S.A., Biermann, B., Mosbacher, J., Kaupmann, K., Bettler, B. (2005). The RXR-Type endoplasmic reticulum-retention/retrieval signal of GABAB1 requires distant spacing from the membrane to function. Mol. Pharmacol. 68,137-144.

Mombereau, C., Kaupmann, K., Gassmann, M., Bettler, B., Van der Putten, H., Cryan, J.F. (2005). Altered anxiety and depression-related behaviour in mice lacking GABAB2 receptor subunits. NeuroReport 16(3), 307-310.

Deriu, D., Gassmann, M., Firbank, S., Ristig, D., Lampert, C., Mosbacher, J., Froestl W., Kaupmann, K., Bettler, B., Grütter, M.G. (2005). Determination of the minimal functional ligand-binding domain of the GABAB(1b) receptor. Biochem. J. 386, 423-431.

Bianchi, M.S., Catalano, P.N., Bonaventura, M.M., Silveyra, P., Bettler, B., Libertun, C. , Lux-Lantos, V.A.R. (2004). Effect of androgens on sexual differentiation of pituitary γ-aminobutyric acid receptor subunit GABAB expression. Neuroendocrinology 80, 129-142.

Tabata, T., Araishi, K., Hashimoto, K., Hashimotodani, Y., Van der Putten, H., Bettler, B., Kano, M. (2004). Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA. Proc. Natl. Acad. Sci. USA 101, 16952-16957.

Haller, C., Casanova, E., Müller, M., Vacher, C.-M., Vigot, R., Doll, T., Barbieri, S., Gassmann, M., Bettler, B. (2004). Floxed allele for conditional inactivation of the GABAB(1) gene. Genesis 40, 125-130.

Rüttimann E., Vacher, C.-M., Gassmann M., Kaupmann, K., Van der Putten H., Bettler, B. (2004). Altered hippocampal expression of calbindin D-28k and calretinin in GABAB(1)-deficient mice. Biochem. Pharmacol. 68(8), 1613-1620.

Fritschy, J.-M., Sidler, C., Parpan, F., Gassman, M., Kaupmann, K., Bettler, B., Benke, D. (2004). Independent maturation of the GABAB receptor subunits GABAB1 and GABAB2 during postnatal development in rodent brain. J. Comp. Neurol. 477, 235-252.

Cryan, J.F., Kelly, P.H., Chaperon, F., Gentsch, C., Mombereau, C., Lingenhoehl, K., Froestl W., Bettler, B., Kaupmann, K. , Spooren, W.P.J.M. (2004). Behavioral characterization of the novel GABAB receptor positive modulator GS39783 (N,N’-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side-effects associated with baclofen or benzodiazepines. J. Pharmacol. Exp. Ther. 310, 952-963.

Gassmann, M., Shaban, H., Vigot, R., Sansig, G., Haller, C., Barbieri, S., Humeau, Y., Schuler, V., Müller, M., Kinzel, B., Klebs, K., Schmutz, M. , Froestl, W., Heid, J., Kelly, P. H., Gentry, C., Jaton, A.-L., Van der Putten, H., Mombereau, C., Lecourtier, L., Mosbacher, J., Cryan, J. F., Fritschy, J.-M., Lüthi, A., Kaupmann, K., Bettler, B. (2004). Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. J. Neurosci. 24, 6086-6097.

Kaupmann, K., Cryan, J.F., Wellendorph, P., Mombereau, C., Sansig, G., Klebs, K., Schmutz, M., Froestl, W., Van der Putten, H., Mosbacher, J., Bräuner-Osborne, H., Waldmeier, P., Bettler, B. (2003). Specific γ-hydroxybutyrate-binding sites but loss of pharmacological effects of γ-hydroxybutyrate in GABAB(1)-deficient mice. Eur. J. Neurosci. 18, 2722-2730.

Furtinger, S.,Bettler, B., Sperk, G. (2003). Altered expression of GABAB receptors in the hippocampus after kainic acid-induced seizures in rats. Mol. Brain. Res. 113, 107-115.

Saghatelyan A.K., Snapyan M., Gorissen S., Meigel I., Mosbacher J., Kaupmann K., Bettler, B., Kornilov A.V., Nifantiev N.E., Sakanyan V., Schachner M., Dityatev A. (2003). Recognition molecule associated carbohydrate inhibits postsynaptic GABAB receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses. Mol. Cell. Neurosci. 24, 271-282.

Froestl, W., Bettler, B., Bittiger, H., Heid, J., Kaupmann, K., Mickel, S.J., Strub, D. (2003). Ligands for expression cloning and isolation of GABAB receptors. Farmaco 58, 173-183.

Havlickova, M., Prezeau, L., Duthey, B., Bettler, B., Pin, J.-P., Blahos, J. (2002). The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor. Mol. Pharmacol. 62, 343-350.

Jensen, A.A., Mosbacher, J., Elg, S., Lingenhoehl, K., Lohmann, T., Johansen, T.N., Abrahamsen, B., Mattson, J.P., Lehmann, A., Bettler, B., Bräuner-Osborne, H. (2002). The anticonvulsant gabapentin (Neurontin) does not act through GABAB receptors. Mol. Pharmacol. 61, 1377-1384.

Kulik, A., Nakadate, K., Nyiri, G., Notomi, T., Malitschek, B., Bettler, B., Shigemoto, R. (2002). Distinct localization of GABAB receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus.Europ. J. Neurosci. 15, 291-307.

Duthey, B., Caudron, S., Perroy, J., Bettler, B., Fagni, L., Pin, J.-P., Prézeau, L. (2002). A single subunit (GB2) is required for G-protein activation by the heterodimeric GABAB receptor. J. Biol. Chem. 277, 3236-3241.

Urwyler, S., Mosbacher J., Lingenhoehl K., Heid, J. Hofstetter, K. Froestl, W., Bettler, B., Kaupmann K. (2001). Positive allosteric modulation of native and recombinant GABAB receptors by 2,6-Di-tert.-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501. Mol. Pharmacol. 60, 963-971. (With accompanying “Perspectives” Article).

Schuler, V., Lüscher C., Blanchet, C, Klix, N., Sansig, G., Klebs, K., Schmutz, M,. Heid, J., Gentry, C., Urban, L., Fox, A., Spooren, W., Jaton, A.-L., Vigouret, J.-M., Pozza, M., Kelly, P.H., Mosbacher, J., Fröstl, W., Käslin, E., Korn, R., Bischoff, S., Kaupmann, K., Van der Putten, H., Bettler, B. (2001). Epilepsy, hyperalgesia, impaired memory, and loss of pre-and postsynaptic GABAB responses in mice lacking GABAB(1). Neuron 31, 47-58.

Froestl, W., Bettler, B., Bittiger, H., Heid, J., Kaupmann, K., Mickel, S.J., Strub, D. (2001). Ligands for expression cloning and isolation of GABAB receptors. Farmaco 56 (1-2), 101-105.

Galvez, T., Duthey, B., Kniazeff, J., Blahos, J., Rovelli, G., Bettler, B., Prézeau, L., Pin, J.-P. (2001). Allosteric interactions between GB1 and GB2 subunits are required for optimal GABAB receptor function. EMBO J. 20 (9), 2152-2159.

Gonchar, Y., Pang, L., Malitschek, B., Bettler, B., Burkhalter, A. (2001). Subcellular localization of GABAB receptor subunits in rat visual cortex. J. Comp. Neurol. 431 (2), 182-197.

Pagano, A., Rovelli, G., Mosbacher, J., Lohmann, T., Duthey, B,, Stauffer, D., Ristig, D., Schuler, V., Meigel, I., Lampert, C., Stein, T., Prézeau, L., Blahos, J., Pin, J.-P., Froestl, W., Kuhn, R., Heid, J. Kaupmann, K., Bettler, B. (2001). C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABAB receptors. J. Neurosci. 21 (4), 1189-1202.

Bianchi. M., Rey-Roldán, E., Bettler, B., Ristig, D., Malitschek, B, Libertun C., Lux-Lantos, V. (2001). Ontogenic expression of anterior pituitary GABAB receptor subunits. Neuropharmacology 40, 185-192.

Galvez, T., Pezeau, L., Milioti, G., Franek, M., Joly, C., Froestl, W., Bettler, B., Bertrand, H.-O., Blahos, J., Pin, J.-P. (2000). Mapping the Agonist-Binding Site of GABAB type 1 Subunit Sheds Light on the Activation Process of GABAB Receptors. J. Biol. Chem. 275, 41166-41174.

Mulle, C., Sailer, A., Swanson, G.T., Brana, C., O'Gorman, S., Bettler, B., Heinemann, S.F. (2000). Subunit composition of kainate receptors in hippocampal interneurons. Neuron 28, 475-484.

Lorente, P., Lacampagne, A., Pouzeratte Y., Richards, S., Malitschek, B., Kuhn, R., Bettler, B., Vassort, G. (2000). γ-aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes. Proc. Natl. Acad Sci. USA 97, 8664-8669.

Towers, S., Princivalle, A., Billinton, A., Edmunds, M., Bettler, B., Urban, L., Castro-Lopes, J., Bowery, N.G. (2000). GABAB receptor protein and mRNA distribution in rat spinal cord and dorsal root ganglia.Europ. J. Neurosci. 12, 3201-3210.

Galvez, T., Urwyler, S., Prézeau L., Mosbacher, J., Joly, C., Malitschek, B., Heid, J., Brabet, I., Froestl, W., Bettler, B., Kaupmann, K., Pin, J.-P. (2000). Ca2+ requirement for high-affinity γ-aminobutyric acid (GABA) binding at GABAB receptors: Involvement of serine 269 of the GABABR1 subunit. Mol. Pharmacol. 57, 419-426.

Keir, M.J., Barakat, M.J., Dev, K.K., Bittiger, H., Bettler, B., Henley, H. (1999). Characterization and partial purification of the GABAB receptor from the rat cerebellum using the novel antagonist [3H]CGP62349. Mol. Brain Res. 71 (2), 279-289.

Franek, M., Pagano, A., Kaupmann, K., Bettler, B., Pin, J.-P., Blahos, J. (1999). The heteromeric GABAB receptor recognizes G-protein α subunit C-termini. Neuropharmacology 38, 1657-1666.

Froestl, W., Bettler, B., Bittiger, H., Heid, J. Kaupmann, K. Mickel, S. J, Strub, D. (1999). Ligands for the isolation of GABAB receptors. Neuropharmacology 38, 1641-1646.

Lingenhoehl, K., Brom, R., Heid, J., Beck, P., Froestl, W., Kaupmann, K., Bettler, B., Mosbacher, J. (1999). γ-Hydroxybutyrate is a weak agonist at recombinant GABAB receptors. Neuropharmacology 38, 1667-1673.

Benke, D., Honer, M., Michel, B., Bettler, B. and Möhler, H. (1999). γ-Aminobutyric acid type B receptor splice variant proteins GBR1a and GBR1b are both associated with GBR2 in situ and display differential regional and subcellular distribution. J. Biol. Chem. 274, 27323-27330.

Pfaff, T., Malitschek, B., Kaupmann, K., Prézeau, L., Pin, J.-P., Bettler, B., Karschin, A. (1999). Alternative splicing generates a novel isoform of the rat metabotropic GABABR1 receptor. Europ. J. Neurosci. 11, 2874-2882.

Bischoff, S, Leonhard, S., Reymann, N., Schuler, V., Shigemoto, R., Kaupmann, K., Bettler, B. (1999). Spatial distribution of GABABR1 receptor mRNA and binding sites in the rat brain. J. Comp. Neurol. 412, 1-16.

Malitschek, B., Schweizer, C., Keir, M., Heid, J., Froestl, W., Mosbacher, J., Kuhn, R., Henley, J., Joly, C., Pin, J.-P., Kaupmann, K., Bettler, B. (1999). The N-terminal domain of GABAB receptors is sufficient to specifiy agonist and antagonist binding. Mol. Pharmacol. 56 (2), 448-454.

Sander, T., Peters, C., Kämmer, G., Samochowiec, J., Zirra, M., Mischke, D., Ziegler, A., Kaupmann, K., Bettler, B., Epplen, J. T., Riess, O. (1999). Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy. Am. J. Med. Genet. (Neuropsychiatric Genetics) 88 (4), 305-310.

Galvez, T., Parmentier, M.-L., Joly, C., Malitschek, B., Kaupmann, K., Kuhn, R., Bittiger, H., Froestl, W., Bettler, B., Pin, J.-P. (1999). Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding. J. Biol. Chem. 274 (19), 13362-13369.

Mosbacher, J., Kaupmann, K., Schuler, V., Ristig, D., Struckmeyer, K., Pfaff, T., Karschin, A, Pozza, M.F. and Bettler, B. (1999). Processing of GABABR1 in heterologous expression systems. Ann-N-Y-Acad-Sci. 868, 689-692.

Peters, H. C., Kämmer, G., Volz, A., Kaupmann, K., Ziegler, A., Bettler, B., Epplen, J. T., Sander, T. and Riess, O. (1998). Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy. Neurogenetics 2, 47-54.

Zhang, C., Bettler, B.,Duvoisin, R.M. (1998). Differential localization of GABAB receptors in the mouse retina. NeuroReport 9, 3493-3497.

Malitschek, B., Rüegg, D., Heid, J., Kaupmann, K., Bittiger, H., Fröstl, W., Bettler, B., Kuhn, R. (1998). Developmental changes of agonist affinity at GABABR1 receptor variants in rat brain. Mol. Cell. Neurosci. 12, 56-64.

Kaupmann, K., Schuler, V., Mosbacher, J., Bischoff, S., Bittiger, H., Heid, J., Froestl, W., Leonhard, S., Pfaff, T., Karschin, A, Bettler, B. (1998). Human γ-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels. Proc. Natl. Acad. Sci. USA 95, 14991-14996.

Couve, A., Filippov, A. K., Connolly, C.N., Bettler, B., Brown, D. A. and Moss, S. J. (1998). Intracellular retention of recombinant GABAB receptors. J. Biol. Chem. 273, 26361-26367.

Kaupmann, K., Malitschek, B, Schuler, V., Heid, J., Froestl, W., Beck, P., Mosbacher, J., Bischoff, S., Kulik, A., Shigemoto, R., Karschin, A., Bettler, B. (1998). GABAB receptor subtypes assemble into functional heteromeric complexes. Nature (London) 396, 683-687.

Mulle, C., Sailer, A., Pérez-Otaño, Dickinson-Anson, H., Castillo, P. E., Bureau, I., Maron, C., Gage, F. H., Mann, J., Bettler, B., Heinemann, S. F. (1998). Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature (London) 392, 601-605.

Koulen, P., Malitschek, B., Kuhn, R., Bettler, B., Wässle, H. and Brandstätter, J. H. (1998). Presynaptic and postsynaptic localization of GABAB receptors in neurons of the rat retina. Eur. J. Neurosci. 10, 1146-1456.

Kaupmann, K., Huggel, H., Heid, J., Flor, P. J., Bischoff, S., Mickel, S. J., McMaster, G., Angst, C., Bittiger, H., Froestl, W, Bettler, B. (1997). Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors. Nature (London) 386, 239-246. (With accompanying “News and Views” Article).

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