Selected Publications

Hiermaier M, Kliewe F, Schinner C, Stüdle C, Maly IP, Wanuske MT, Rötzer V, Endlich N, Vielmuth F, Waschke J, Spindler V (2020).  The actin binding protein α-adducin modulates desmosomal turnover and plasticity. J Invest Dermatol, accepted

Vielmuth F, Wanuske MT, Radeva MY, Hiermaier M, Kugelmann D, Walter E, Buechau F, Magin TM, Waschke J, Spindler V (2018). Keratins regulate the adhesive properties of desmosomal cadherins through signaling. J Invest Dermatol 138(1):121-131

Schinner C, Vielmuth F, Rötzer V, Hiermaier M, Radeva M, Thu K Co, Hartlieb E, Schmidt A, Imhof A, Messoudi A, Horn A, Schlipp A, Spindler V, Waschke J (2017). Adrenergic signaling strengthens cardiac myocyte cohesion. Circ Res. 2017 Apr 14;120(8):1305-1317

Hütz K, Zeiler J, Sachs L, Ormanns S., Spindler V (2017). Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells. Mol Carcinog. 56(8):1884-1895

Rötzer V, Hartlieb E, Winkler J, Walter E, Schlipp A, Sardy M, Spindler V*, Waschke J* (2016). Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing. J Invest Dermatol. 136(1):301-10.  * corresponding authors

Vielmuth F, Waschke J, Spindler V (2015). Loss of Desmoglein Binding Is Not Sufficient for Keratinocyte Dissociation in Pemphigus. J Invest Dermatol. 135(12):3068-77

Vielmuth F, Hartlieb E, Kugelmann D, Waschke J, Spindler V (2015). Atomic force microscopy identifies regions of distinct desmoglein 3 adhesive properties on living keratinocytes. Nanomedicine. 11(3):511-20

Dehner C, Rötzer V, Waschke J, Spindler V (2014). A desmoplakin point mutation with enhanced keratin association ameliorates pemphigus vulgaris autoantibody-mediated loss of cell cohesion. Am J Pathol, 184(9):2528-36.

Rötzer V, Breit A, Waschke J, Spindler V (2014). Adducin is required for keratinocyte cohesion. J Biol Chem, 289(21):14925-40

Spindler V, Dehner C, Hübner S, Waschke J (2014). Plakoglobin but not desmoplakin regulates keratinocyte cohesion via p38MAPK signaling. J Invest Dermatol, 134(6):1655-64

Spindler V, Rötzer V, Dehner C, Kempf B, Gliem M, Radeva M, Hartlieb E, Harms GS, Schmidt E, Waschke J (2013). Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering. J Clin Invest, 123(2):800–811

Spindler V, Vielmuth F, Schmidt E, Rubenstein D, Waschke J (2010). Protective cAMP signaling triggered by pemphigus autoantibodies. J Immunol 185(11):6831-8

Waschke J1, Spindler V1, Bruggeman P, Zillikens D, Schmidt G, Drenckhahn D (2006). Inhibition of Rho A activity causes pemphigus skin blistering. J Cell Biol, 175(5):721-7, 2006    1 shared

Selected Reviews

Spindler V, Eming R, Schmidt E, Amagai M, Grando S, Jonkman MF, Kowalczyk AP, Müller EJ, Payne AS, Pincelli C, Sinha AA, Sprecher E, Zillikens D, Hertl M, Waschke J (2018). Mechanisms causing loss of keratinocyte cohesion in pemphigus. J Invest Dermatol, 138(1):32-37.

Waschke J, Spindler V (2014). Desmosomes and extradesmosomal adhesive signaling contacts in pemphigus. Med Res Rev, 2014 Nov;34(6):1127-45.

Spindler V, Schlegel N, Waschke J (2010). Rho GTPases in control of microvascular permeability. Cardiovasc Res, 87(2):243-53