Postdoctoral Positions in Genome and Developmental Biology
There is an opening for at least one Postdoctoral Fellow to study the architecture of gene regulatory networks. Our research aims to get fundamental insights into how signaling inputs orchestrate epigenetic changes in in chromatin structure and regulate the transcription of the target genes that control the proliferative expansion and fates of progenitor and stem cells during mouse embryonic organogenesis. The fully funded positions are available as part of ERC and SNF funded research projects in the Developmental Genetics Group at the Department of Biomedicine of the University of Basel (Switzerland). Publications relevant to these positions include: Bénazet et al. 2009, Science 323, 1050-1053; Zuniga et al., 2012, BMC Dev. Biol. 12, 23 doi:10.1186; Lopez-Rios et al. 2014, Nature 511, 46-51; Osterwalder et al. 2014, Dev Cell 31, 345–357; Zuniga 2015, Development 142, 3810-3820, Laurent et al. 2017 Cell Reports (in press).
The group is using the developing limb bud as one of their experimental paradigms to studying the signaling and gene regulatory circuits that control the proliferative expansion and patterning of mesenchymal progenitors during early organogenesis. We have shown that early limb bud development is controlled by robust gene regulatory circuits that integrate inputs from the major signaling pathways into the transcriptional control of key regulators of proliferation and cell fate specification. We are combining molecular genetics and CRISPR/Cas9-mediated genome editing with ChIP-Seq, transcriptome and genome-wide chromatin analysis to identify and study the functionally relevant cis-regulatory modules (CRMs), epigenetic modifications and transcriptional complexes that integrate signaling inputs into a robust transcriptional output. A second major aspect of our research is to identify the changes in genome architecture and transcriptional regulation that underlie adaptation of this self-regulatory system during evolutionary diversification of limbs during vertebrate organogenesis. In addition our research is also exploring alterations in the relevant CRMs and expression of key transcriptional regulators that renders the regulatory circuits fragile to congenital malformations and disease. Therefore several projects in the framework of our groups research are possible.
We are looking to recruit highly motivated postdoctoral fellows, who have very recently completed or are in progress of completing their PhDs. The successful candidates should have expertise in mouse molecular genetics and/or genome editing. In addition, they have research expertise in molecular and analysis of developmental, cellular and/or evolutionary processes using animal models. Applicants must have published at least one first author publication from their PhD in an internationally recognized journal.
We offer the opportunity to join a dynamic and international research team in a biomedical research environment. You will have the chance to do competitive research in a stimulating and interactive research environment. In addition, you will have the opportunity to supervise and guide PhD and master students on a daily basis and train in other skills such as participating in manuscript and grant writing, which should prepare you to step into independence after completing your postdoctoral period. Life Sciences Research at University of Basel is top-ranked and offers excellent interdisciplinary and interfaculty research and training opportunities for postdoctoral fellows (https://biomedizin.unibas.ch/education-careers/post-doc/) in addition to excellent salaries and living conditions in the city of Basel (bordering Germany and France).
Submission of Applications and further Information
For more information see our group website:
Applicants should send a CV with complete publication list, motivation letter, summary of PhD research, key publications and grades of Master and PhD thesis and the names and addresses of three referees as one single PDF file directly to rolf.zeller-at-unibas.chand/or aimee.zuniga-at-unibas.ch.
Interviews will continue until the positions are filled.