Tumor Heterogeneity Metastasis and Resistance

Prof. Dr. Mohamed Bentires-Alj

Department of Biomedicine
University Hospital Basel
Hebelstrasse 20 4031 Basel
T:+41 (0)61 265 33 13

Research Focus

Basic and translational research on breast tumor heterogeneity, metastasis and therapy Resistance.

Breast tumor heterogeneity is the thread connecting the research in our lab. At the molecular, cellular, and whole organism levels, we assess mechanisms that influence normal and neoplastic breast stem cells, metastasis, and resistance to therapy. We explore both cell autonomous (genetics, epigenetics, and proteomics) and non-cell autonomous mechanisms (immune cells, adipcoytes, and other stromal factors). We use systems medicine quantitative methods, synthetic lethal screens, unbiased pooled shRNA, CRISPR, transposon-based screens, and hypothesis-driven approaches. Computational biology is a very important part of our research. Moreover, we use multiphoton intravital imaging to assess the interactions between cancer cells and immune cells.

These interdisciplinary projects seek to elucidate the integrated effects of signaling pathways and epigenetics on breast cell fate and tumor heterogeneity, and to leverage this mechanistic understanding into therapy. We are part of the department of Surgery and in collaboration with clinicians, we have built a Breast Cancer Personalized Medicine Team which should ultimately improve treatment for patients in Basel and throughout the world.

For more information please visit our website: https://bentireslab.org/