Cellular Neurophysiology


Selected Publications 

Normann C, Frase S, Haug V, Von Wolff G, Clark K, Münzer P, Dorner A, Scholliers J, Horn M, Vo Van T, Seifert G, Serchov T, Biber K, Nissen C, Klugbauer N, Bischofberger J (2017). Antidepressants rescue stress-induced disruption of synaptic plasticity via serotonin transporter-independent inhibition of L-type Ca2+-channels. Biological Psychiatry, in press.

Li L, Sultan S, Heigele S, Schmidt-Salzmann C, Toni N, Bischofberger J (2017). Silent synapses generate sparse and orthogonal action potential firing in adult-born hippocampal granule cells. eLife 8:6.

Fedele S, Collo G, Behr K, Bischofberger J, Müller S, Kunath T, Christensen K, Gündner AL, Graf M, Jagasia R, Taylor V (2017). Expansion of human midbrain floor plate progenitors from induced pluripotent stem cells increases dopaminergic neuron differentiation potential. Sci Rep. 7: 6036.

Iijima Y, Behr K, Iijima T, Biemans B, Bischofberger J, Scheiffele P (2016). Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure. Sci Rep. 6: 27400.

Costa V, Aigner S, Vukcevic M, Sauter E, Behr K, Ebeling M, Dunkley T, Friedlein A, Zoffmann S, Meyer CA, Knoflach F, Lugert S, Patsch C, Fjeldskaar F, Chicha-Gaudimier L, Kiialainen A, Piraino P, Bedoucha M, Graf M, Jessberger S, Ghosh A, Bischofberger J, Jagasia R (2016). mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis. Cell Rep. 15(1):86-9.

Heigele S, Sultan S, Toni N, Bischofberger J (2016). Bidirectional GABAergic control  of action potential firing in newborn hippocampal granule cells. Nat Neurosci. 19(2):263-270.

Oettinghaus B, Schulz JM, Restelli LM, Licci M, Savoia C, Schmidt A, Schmitt K, Grimm A, Morè L, Hench J, Tolnay M, Eckert A, D'Adamo P, Franken P, Ishihara N, Mihara K, Bischofberger J, Scorrano L, Frank S (2016). Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons. Cell Death Differ 23(1):18-28.

Bolz L, Heigele S, Bischofberger J (2015). Running Improves Pattern Separation during Novel Object Recognition. Brain Plasticity 1: 129-141.

Sultan S, Li L, Moss J, Petrelli F, Cassé F, Gebara E, Lopatar J, Pfrieger FW, Bezzi P, Bischofberger J, Toni N (2015). Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes. Neuron 88(5): 957-972.

Pohle J, Bischofberger J (2014)  Supralinear dendritic Ca2+ signaling in young developing CA1 pyramidal cells. J Physiol. 592(22):4931-4949.

Giachino C, Barz M, Tchorz JS, Tome M, Gassmann M, Bischofberger J, Bettler B, Taylor V (2014) GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors. Development 141: 83-90.

Schmidt-Salzmann C, Li L, Bischofberger J (2014) Functional properties of extrasynaptic AMPA and NMDA receptors during postnatal hippocampal neurogenesis. J Physiol 592.1: 125-140.

Lepski G, Jannes CE, Nikkhah G, Bischofberger J (2013) cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels. Frontiers Cell Neurosci 7:155.

Herpfer I, Hezel H, Reichardt W, Clark K, Geiger J, Gross CM, Heyer A, Neagu V, Bhatia H, Atas HC, Fiebich BL, Bischofberger J, Haas CA, Lieb K, Normann C. (2012) Early life stress differentially modulates distinct forms of brain plasticity in young and adult mice. PLoS One 7 (10): e46004.

Lepski G, Maciaczyk J, Jannes CE, Maciaczyk D, Bischofberger J, Nikkhah G (2011) Delayed functional maturation of human neuronal progenitor cells in vitro. Mol Cell Neurosci 47: 36-44.

Schmidt-Hieber C, Bischofberger J (2010) Fast sodium channel gating supports localized and efficient axonal action potential initiation. J Neurosci 30: 10233-10242

Bucurenciu I, Bischofberger J, Jonas P (2010) A small number of open presynaptic Ca2+ channels triggers precisely timed transmitter release at a central GABAergic synapse. Nature Neuroscience 13:19-21.

Niehusmann P, Seifert G, Clark K, Atas HC, Herpfer I, Fiebich B, Bischofberger J, Norman C (2010) Coincidence Detection and Stress Modulation of Spike Time-Dependent Long-Term Depression in the Hippocampus. J Neurosci 30: 6225-6235.

Stocca G, Schmidt-Hieber C, Bischofberger J (2008) Differential dendritic Ca2+ signalling in young and mature hippocampal granule cells. J Physiol 586: 3795-3811.

Schmidt-Hieber C, Jonas P, Bischofberger J (2008) Action potential initiation and propagation in hippocampal mossy fibre axons. J Physiol 586: 1849-1857.

Li Liyi, Bischofberger J, Jonas P (2007) Differential gating and recruitment of P/Q-, N-, and R-type Ca2+ channels in hippocampal mossy fiber boutons. J Neurosci 27: 13420-13429.

Schmidt-Hieber C, Jonas P, Bischofberger J (2007) Subthreshold dendritic signal processing and coincidence detection in dentate gyrus granule cells. J Neurosci 27: 8430-8441.

Holderbach R, Clark K, Moreau J-L, Bischofberger J, Normann C (2007) Enhanced synaptic long-term depression in an animal model of depression. Biol Psychiatry 62: 92-100.

Bischofberger J, Engel D, Liyi L, Geiger JR, Jonas P (2006a) Patch-clamp recording from mossy fiber terminals in hippocampal slices. Nature Protocols 1: 2075-2080.

Berkefeld H, Sailer CA, Bildl W, Thumfahrt J, Rhode V, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus H-G, Schulte U, Fakler B (2006) BKCa-Cav channel complexes as a mechanism of rapid and localized Ca2+-activated K+ signalling. Science 314: 615-620.

Bischofberger J (2007) Young and excitable: New neurons in memory networks. Nature Neuroscience 10: 273-275.

Schmidt-Hieber C, Jonas P, Bischofberger J (2004) Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature 429: 184-187.

Bischofberger J, Geiger JRP, Jonas P (2002) Timing and efficacy of Ca2+ channel activation in hippocampal mossy fiber boutons. J Neurosci 22: 10593-10602.

Jonas P, Bischofberger J, Sandkühler J (1998) Co-release of two fast neurotransmitters at a central synapse. Science 281: 419-424.