Andrew studied Biomedical Sciences at Warwick University, U.K. After a short period in the pharmaceutical industry Andrew went on to complete a PhD in lipid antigen presentation by CD1 molecules and currently holds the position of Postdoctoral research fellow in the lab of Prof. Gennaro De Libero investigating small molecule presentation by MHC Class I-related protein (MR1).
Antigen presentation, Unconventional T-cells, Cancer immunology, Mycobacterium tuberculosis
Investigation of a novel class of antigens presented by MR1 to T cells.
Gene engineering in MR1T cells
Sibley L, Gooch K, Wareham A, Gray S, Chancellor A, Dowell S, Bate S, Marriott A, Dennis M, White AD, Marsh P, Fletcher H, Sharpe S. Difference in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques. 2019 Sci. Rep. (1):3340
Barton E, Gao Y, Ball D, Fidler K, Klein N, Curtis N, Clifford V, Marshall BG, Chancellor A, Mansour S, Elkington P, Tebruegge M. Calcineurin inhibitors and variation in the performance of interferon-g release assays used to detect tuberculosis infection. 2019 Ann. Am. Thorac. Soc. (6):771-775
Melandri D, Zlatareva I, Chaleil RAG, Dart RJ, Chancellor A, et al. The gdTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness. 2018. Nat. Immunol. (12):1352-1365
Chancellor A, Gadola SD, Mansour S. The versatility of the CD1 lipid antigen presentation pathway. Immunology. 2018;0–2.
Chancellor A, Tocheva AS, Cave-Ayland C, Tezera L, White A, Al Dulayymi JR, et al. CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains. Proc Natl Acad Sci U S A. 2017/11/22. 2017;
Tezera LB, Bielecka MK, Chancellor A, Reichmann MT, Shammari B Al, Brace P, et al. Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model. Elife. 2017;6.
Chancellor A, White A, Tocheva AS, Fenn JR, Dennis M, Tezera L, et al. Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection. Tuberculosis. 2017;105:86–95.
Tocheva AS, Mansour S, Holt TGH, Jones S, Chancellor A, Sanderson JP, et al. The Clonal Invariant NKT Cell Repertoire in People with Type 1 Diabetes Is Characterized by a Loss of Clones Expressing High-Affinity TCRs. J Immunol. 2017;198(4):1452–9.