Lucia Mori has a Ph.D. in Microbiology and Immunology from the University of Pisa, Italy. Her background is in molecular immunology. She studied the specificity of antigen recognition of T lymphocytes and T cell receptor (TCR) genes at the National Research Council in Milano and at the Basel Institute for Immunology. At Hoffmann-La Roche Headquarters Basel, she established new experimental models to investigate the role of TCR genes in autoimmunity. Since 1994 Dr. Mori has been based at the Department of Biomedicine of the University and University Hospital Basel where she has participated in the discovery of self-metabolites stimulating human TCRγδ cells, and of self-lipids stimulating TCRαβ cells, including NKT cells. Between 2010 and 2016 she led a research group focused on “non classical” T cell immunity at the Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR). Since returning to the Department of Biomedicine in Basel, Dr. Mori leads translational immunology projects aimed at the identification of T cell signatures as relevant disease-specific biomarkers and the exploitation of non-classical T cells in novel immunotherapeutic strategies.
T cells, Antigen-presentation, T-cell receptors, Non-classical T cells, Tumor-associated non-peptidic antigens.
Identification of tumor-associated antigens presented by MR1.
Immunotherapy of solid tumors based on MR1T cells.