Prof. Dr. Petya Apostolova
Research group leader
Petya Apostolova
Medizinische Fakult├Ąt
FG Apostolova

Research group leader

Departement Biomedizin
DBM Hebelstrasse - FG Apostolova
Hebelstrasse 20
4031 Basel
Schweiz

Tel. +41 61 328 48 40
petya.apostolova@unibas.ch

  • Tumor immunology

  • Cancer and immune cell metabolism

  • Allogeneic hematopoietic stem cell transplantation

  • Cancer immunotherapy

2006 - 2013Medical School, University of Freiburg, Germany with practical trainings in Vienna, Sofia and Basel
2013MD thesis, Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Germany
2013 - 2019Residency and Fellowship in Internal Medicine, Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Germany
2019 - 2021Postdoctoral research fellow, Department of Immunometabolism, Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany
2021 - 2023Postdoctoral research fellow, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
2022Board Certification in Internal Medicine
11/2023 - current

Assistant Professor of Experimental Hematology, University of Basel

Attending Physician in the Division of Hematology, University Hospital Basel

* equal contribution

Apostolova, P.*, Kreutmair, S.*, Toffalori, C.*, Punta, M.*, Unger, S.*, Burk, A. C., Wehr, C., Maas-Bauer, K., Melchinger, W., Haring, E., Hoefflin, R., Shoumariyeh, K., Hupfer, V., Lauer, E. M., Duquesne, S., Lowinus, T., Gonzalo Nunez, N., Alberti, C., da Costa Pereira, S., . . . Zeiser, R. (2023). Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantation-Immune signature correlates with response. Br J Haematol, 203(2), 264-281. PMID 37539479

Edwards-Hicks, J.*, Apostolova, P.*, Buescher, J. M., Maib, H., Stanczak, M. A., Corrado, M., Klein Geltink, R. I., Maccari, M. E., Villa, M., Carrizo, G. E., Sanin, D. E., Baixauli, F., Kelly, B., Curtis, J. D., Haessler, F., Patterson, A., Field, C. S., Caputa, G., Kyle, R. L., . . . Pearce, E. L. (2023). Phosphoinositide acyl chain saturation drives CD8(+) effector T cell signaling and function. Nat Immunol, 24(3), 516-530. PMID 36732424

Apostolova, P., & Pearce, E. L. (2022). Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment. Trends Immunol, 43(12), 969-977. PMID 36319537

Haring, E., Andrieux, G., Uhl, F. M., Krausz, M., Proietti, M., Sauer, B., Esser, P. R., Martin, S. F., Pfeifer, D., Schmitt-Graeff, A., Duyster, J., Kohler, N., Grimbacher, B., Boerries, M., Aumann, K., Zeiser, R., & Apostolova, P. (2022). Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease. Haematologica, 107(7), 1538-1554. PMID 34407601

Haring, E., Zeiser, R., & Apostolova, P. (2021). Interfering With Inflammation: Heterogeneous Effects of Interferons in Graft-Versus-Host Disease of the Gastrointestinal Tract and Inflammatory Bowel Disease. Front Immunol, 12, 705342. PMID 34249014

Stanczak, M. A.*, Sanin, D. E.*, Apostolova, P.*, Nerz, G., Lampaki, D., Hofmann, M., Steinmann, D., Krohn-Grimberghe, M., Thimme, R., Mittler, G., Waller, C. F.*, Pearce, E. J.*, & Pearce, E. L.* (2021). IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals. Nat Commun, 12(1), 2133. PMID 33837219

Klein Geltink, R. I., Edwards-Hicks, J., Apostolova, P., O'Sullivan, D., Sanin, D. E., Patterson, A. E., Puleston, D. J., Ligthart, N. A. M., Buescher, J. M., Grzes, K. M., Kabat, A. M., Stanczak, M., Curtis, J. D., Hassler, F., Uhl, F. M., Fabri, M., Zeiser, R., Pearce, E. J., & Pearce, E. L. (2020). Metabolic conditioning of CD8(+) effector T cells for adoptive cell therapy. Nat Metab, 2(8), 703-716. PMID 32747793

Haring, E.*, Uhl, F. M.*, Andrieux, G., Proietti, M., Bulashevska, A., Sauer, B., Braun, L. M., de Vega Gomez, E., Esser, P. R., Martin, S. F., Pfeifer, D., Follo, M., Schmitt-Graeff, A., Buescher, J., Duyster, J., Grimbacher, B., Boerries, M., Pearce, E. L., Zeiser, R., & Apostolova, P. (2021). Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Haematologica, 106(8), 2131-2146. PMID 32675222

Apostolova, P., Unger, S., von Bubnoff, D., Meiss, F., Becher, B., & Zeiser, R. (2020). Extracorporeal Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy. N Engl J Med, 382(3), 294-296. PMID 31940706

Tsukamoto, H.*, Chernogorova, P. (Apostolova, P.)*, Ayata, K., Gerlach, U. V., Rughani, A., Ritchey, J. W., Ganesan, J., Follo, M., Zeiser, R.*, Thompson, L. F.*, & Idzko, M.* (2012). Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease. Blood, 119(19), 4554-4564. PMID 22262774