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Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells (Taylor Lab)
Gliomas are aggressive brain tumors and resistant to current standard and targeted therapeutic interventions. Immune evasion is pronounced in glioma, but the underlying mechanisms remain poorly understood. Parmigiani et al. demonstrate that suppression of Notch signaling enables glioma cells to evade immune surveillance and increases aggressiveness. The findings of the study provide insights into how brain tumor cells shape their microenvironment to evade control by the immune system.