/ News, Research
Lab Develops Advanced Flow Cytometry Panel for Comprehensive Immunophenotyping of Murine Lungs in Cancer Research (Bentires-Alj Lab)
The Bentires-Alj Lab, with Zora Baumann as the lead author, recently published a study titled “Optimized full-spectrum flow cytometry panel for deep immunophenotyping of murine lungs” in Cell Reports Methods.
The study addresses the need for a comprehensive, high-parameter flow cytometry panel capable of resolving the diverse immune cell populations in murine lungs, an organ particularly challenging due to its high autofluorescence. This optimized panel not only includes nearly all immune cell subtypes but also characterizes their maturation, activation, and inhibition states. By integrating traditional panel optimization strategies with an innovative approach for analyzing cellular autofluorescent signatures, the researchers achieved a robust solution. They further applied the panel in two murine models of lung metastatic mammary cancer, demonstrating its applicability in cancer immunology research.
The DBM congratulates the Bentires-Alj Lab and collaborators on this impactful contribution to the field of flow cytometry and cancer immunology.