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Neutrophils and CTCs

/ News, Research

Nicola Aceto and co-workers identified immune cells that enhance the metastatic potential of circulating tumor cells

The research team discovered the mechanism by which neutrophils, a specific set of immune cells, protect circulating tumor cells (CTCs) in the bloodstream of cancer patients. The interaction between CTCs and neutrophils is mediated by a...
Cancer Cell Logo

/ News, Research, People

The Christofori lab discovered a novel combination therapy, which triggers a conversion of malignant breast cancer cells into fat cells.

The researchers took advantage of the property of tumor cells to adapt dynamically to changing conditions. Using two established drugs, they could re-differentiate cancer cells to non-dividing fat cells.
CTC cluster in microfluidic device

/ Research, People

The Aceto Lab finds that clustering of circulating tumor cells results in DNA hypomethylation and metastasis formation. These effects can be reversed by an approved drug.

The most dangerous aspect of breast cancer is the formation of metastases, which are seeded by circulating tumor cell clusters (CTC clusters). The team around Nicola Aceto has now discovered that the binding sites for stemness- and...

/ Research, People

The European Research Council awards Lukas Jeker an ERC Consolidator Grant

With the 2.4 Million Euro grant by the European Research Council, the Jeker lab will further investigate the inner workings of immune cells on a molecular level with the aim to use genetic immune cell reprogramming to develop novel...
The Botnar Research Centre for Child Health (BRCCH)

/ Research

Georg Holländer (DBM) and Sai Reddy (D-BSSE) will head the new Botnar Research Centre for Child Health

DBM research group leader Georg Holländer will be the foundig director of the Botnar Research Centre for Child Health at the University of Basel and ETH Zürich.Uninews
SNSF

/ Research, People

Sara Meyer receives SNSF Eccellenza Professorial Fellowship

The DBM congratulates PD Dr. Dr. Sara Meyer, who was awarded a SNSF Eccellenza Professorial Fellowship (http://www.snf.ch/en/funding/careers/eccellenza/Pages/default.aspx)  for her project "Mechanisms and targeting of oncogenic MAPK...

/ People

DBM research group leaders Peter Itin and Ivan Martin were elected to members of the Swiss Academy of Medical Sciences

The Swiss Academy of Medical Sciences (SAMS) Senate has elected Prof. Peter Itin as honorary member and Prof. Ivan Martin as member of the SAMS Senate. They will receive their certificate at the award ceremony on November 29, 2018. ...
ERC

/ News, Research, People

The European Research Council awards Ivan Martin (DBM) and Filippo Rijli (FMI) one of the prestigious ERC Synergy Grants.

With their 5.3 Million Euro grant the interdisciplinary team led by Filippe Rijli (Friederich Miescher Institute for Biomedical Research) and Ivan Martin aims to find out whether nasal cartilage cells, which have properties of neural crest...

/ News, Events, Doctorate/PhD

The DBM is hosting the first International PhD Course on Frontiers in Metastasis Biology.

The course is organized by Momo Bentires-Alj (DBM),  Anna Obenauf (IMP Vienna), and Sakari Vanharanta (MRC Cancer Unit, University of Cambridge). During the three days a group of 25 PhD students from the UK, Austria, Switzerland, Italy, the...

In a collaborative effort Heinz Läubli and co-workers have identified a new potential target to improve T cell activation in immunotherapy.

The researchers focused on the sialoglycan-SAMP/Siglec pathway, in particular on Siglec-9, an inhibitory receptor that is expressed on a broad range of immune cells on which it recognizes sialic acids expressed by tumors. They demonstrate...