Kashyap Cell Reports 2019

/ News, Research

Members of the Zippelius lab and collaborators revealed how microtubule destabilitzing chemotherapy promotes protective anti-tumor immunity.

In collaboration with researchers from Massachusetts General Hospital and Harvard Medical School, Abhishek Kashyap and colleagues found that microtubule destabilization in dendritic cells results in the release of the guanine nucleotide...

/ News, Research

The Hess and Recher labs identify the disease mechanism of a hitherto unknown primary antibody defciency

The researchers identified a gain-of-function mutation in the metabolic enzyme SDHA, which leads to an accumulation of fumarate and causes inflamatory mitochondrial retrograde signaling as a disease modifier in primary antibody...
The image depicts Id4 (blue) and GFAP (black) expression in genetically labeled stem cells and their progeny (magenta) in the hippocampus of the mouse brain. The image presents an artistic coloration of the spatial and molecular factors in a niche. (Image: University of Basel)

/ News, Research

Verdon Taylor and collaborators identified a signalling pathway that maintains neural stem cell quiescence in adult mouse brain

In their study that was recently published in Cell Reports they discovered a central role fot the Notch2 effector Id4. Id4 not only blocks cell cycle entry but also promotes astrocytic differentiation of hippocampal neural stem cells. ...
Basel Stadt

/ News, People, Research

Nina Khanna Gremmelmaier receives the 2019 research prize by the city of Basel

The DBM congratulates Nina Khanna Gremmelmaier, research group leader of the Infection Biology lab, to this acheivement! Official press release Uninews BZ
Natural killer cells (red) attack ordinary leukaemia cells (green), but not leukaemia stem cells (blue).

/ News, Research

Claudia Lengerke and collaborators discovered how Leukaemia Stem Cells develop resistance against immune cells and suggest novel treatment strategies for patients

The Lengerke Lab elucidated how Leukaemia Stem Cells evade the attack by Natural Killer cells and suggest novel strategies for therapy. Their findings have recently been published in Nature.  Uninews

/ News, Research, Doctorate/PhD, People

Three prestigious national MD-PhD scholarships awarded to DBM students

The Swiss Academy of Medical Sciences (SAMS), the Swiss National Science Foundation (SNSF) and the Swiss Cancer Research Foundation award each year a limited number of competitive three-year MD-PhD scholarships. Repeating the success of...
Prof. Judith E Allen, University of Manchester

/ News, People

The DBM welcomes Prof. Judith E. Allen as new Scientific Advisory Board Member for the Immunology Focal Area

The "Koordinationsgremium Medizin" / KOG has elected Prof. Judith E. Allen to the DBM Scientific Advisory Board in July 2019. She is succeeding Prof. Brigitta Stockinger, who rotated off our Board afer nine years. Judi Allen has a B.Sc....
Biopolar Disorder

The Cichon group and members of the Psychiatric Genomics Consortium have dioscovered 20 new loci associated with bipolar disorder

These GWAS study coordinated by the Psychiatric Genomics Consortium identified nine gene sets that provide potential biological mechanisms for bipolar disorder and that address key clinical questions The study was recently publisehd in...
Neurons in the Amygdala, image: Friedrich Miescher Institute for Biomedical Research

Jan Gründemann and FMI's Lüthi lab investigated the activity of mouse basal amygdala neurons during different behavioural tasks

Jan Gründemann and researches of the laboratory of Andreas Lüthi at the Friederich Miescher Institute for Biomedical Sciences (FMI) have shown that two ensembles of neurons display orthogonal activity during exploratory and nonexploratory...
European Research Council

The European Research Council awards Nicola Aceto a Proof of Concept Grant

With the ERC Proof of Concept Grant, the Aceto lab will furhter develop small molecule inhibitors of circulating tumor cell clusters.