Prof. Dr. Petya Apostolova
Research group leader
Research group leader
Departement Biomedizin
DBM Hebelstrasse - FG Apostolova
Hebelstrasse 20
4031
Basel
Schweiz
Research focus
Tumor immunology
Cancer and immune cell metabolism
Allogeneic hematopoietic stem cell transplantation
Cancer immunotherapy
Curriculum Vitae
| 2006 - 2013 | Medical School, University of Freiburg, Germany with practical trainings in Vienna, Sofia and Basel |
| 2013 | MD thesis, Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Germany |
| 2013 - 2019 | Residency and Fellowship in Internal Medicine, Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Germany |
| 2019 - 2021 | Postdoctoral research fellow, Department of Immunometabolism, Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany |
| 2021 - 2023 | Postdoctoral research fellow, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA |
| 2022 | Board Certification in Internal Medicine |
| 11/2023 - current | Assistant Professor of Experimental Hematology, University of Basel Attending Physician in the Division of Hematology, University Hospital Basel |
Selected Publications
* equal contribution
Apostolova, P.*, Kreutmair, S.*, Toffalori, C.*, Punta, M.*, Unger, S.*, Burk, A. C., Wehr, C., Maas-Bauer, K., Melchinger, W., Haring, E., Hoefflin, R., Shoumariyeh, K., Hupfer, V., Lauer, E. M., Duquesne, S., Lowinus, T., Gonzalo Nunez, N., Alberti, C., da Costa Pereira, S., . . . Zeiser, R. (2023). Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantation-Immune signature correlates with response. Br J Haematol, 203(2), 264-281. PMID 37539479
Edwards-Hicks, J.*, Apostolova, P.*, Buescher, J. M., Maib, H., Stanczak, M. A., Corrado, M., Klein Geltink, R. I., Maccari, M. E., Villa, M., Carrizo, G. E., Sanin, D. E., Baixauli, F., Kelly, B., Curtis, J. D., Haessler, F., Patterson, A., Field, C. S., Caputa, G., Kyle, R. L., . . . Pearce, E. L. (2023). Phosphoinositide acyl chain saturation drives CD8(+) effector T cell signaling and function. Nat Immunol, 24(3), 516-530. PMID 36732424
Apostolova, P., & Pearce, E. L. (2022). Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment. Trends Immunol, 43(12), 969-977. PMID 36319537
Haring, E., Andrieux, G., Uhl, F. M., Krausz, M., Proietti, M., Sauer, B., Esser, P. R., Martin, S. F., Pfeifer, D., Schmitt-Graeff, A., Duyster, J., Kohler, N., Grimbacher, B., Boerries, M., Aumann, K., Zeiser, R., & Apostolova, P. (2022). Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease. Haematologica, 107(7), 1538-1554. PMID 34407601
Haring, E., Zeiser, R., & Apostolova, P. (2021). Interfering With Inflammation: Heterogeneous Effects of Interferons in Graft-Versus-Host Disease of the Gastrointestinal Tract and Inflammatory Bowel Disease. Front Immunol, 12, 705342. PMID 34249014
Stanczak, M. A.*, Sanin, D. E.*, Apostolova, P.*, Nerz, G., Lampaki, D., Hofmann, M., Steinmann, D., Krohn-Grimberghe, M., Thimme, R., Mittler, G., Waller, C. F.*, Pearce, E. J.*, & Pearce, E. L.* (2021). IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals. Nat Commun, 12(1), 2133. PMID 33837219
Klein Geltink, R. I., Edwards-Hicks, J., Apostolova, P., O'Sullivan, D., Sanin, D. E., Patterson, A. E., Puleston, D. J., Ligthart, N. A. M., Buescher, J. M., Grzes, K. M., Kabat, A. M., Stanczak, M., Curtis, J. D., Hassler, F., Uhl, F. M., Fabri, M., Zeiser, R., Pearce, E. J., & Pearce, E. L. (2020). Metabolic conditioning of CD8(+) effector T cells for adoptive cell therapy. Nat Metab, 2(8), 703-716. PMID 32747793
Haring, E.*, Uhl, F. M.*, Andrieux, G., Proietti, M., Bulashevska, A., Sauer, B., Braun, L. M., de Vega Gomez, E., Esser, P. R., Martin, S. F., Pfeifer, D., Follo, M., Schmitt-Graeff, A., Buescher, J., Duyster, J., Grimbacher, B., Boerries, M., Pearce, E. L., Zeiser, R., & Apostolova, P. (2021). Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Haematologica, 106(8), 2131-2146. PMID 32675222
Apostolova, P., Unger, S., von Bubnoff, D., Meiss, F., Becher, B., & Zeiser, R. (2020). Extracorporeal Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy. N Engl J Med, 382(3), 294-296. PMID 31940706
Tsukamoto, H.*, Chernogorova, P. (Apostolova, P.)*, Ayata, K., Gerlach, U. V., Rughani, A., Ritchey, J. W., Ganesan, J., Follo, M., Zeiser, R.*, Thompson, L. F.*, & Idzko, M.* (2012). Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease. Blood, 119(19), 4554-4564. PMID 22262774