Selected Publications

Original peer-reviewed papers (2000-2020)

1.     Lehoczky G, Trofin RE, Vallmajo-Martin Q, Chawla S, Pelttari K, Mumme M, Haug M, Egloff C, Jakob M, Ehrbar M, Martin I, Barbero A. Novel single-stage arthroscopic cartilage regeneration therapy with rapidly isolated human nasal chondrocytes. Biomaterials (2021) Under revision   

2.     Acevedo L, Mumme M, Manferdini C, Darwiche S, Khalil A, Hilpert M, Buchner DA, Lisignoli G, Occhetta P, von Rechenberg B, Haug M, Schäfer D, Jakob M, Caplan A, Martin I, Barbero A*, Pelttari K*. Engineered nasal cartilage for the repair of osteoarthritic knee cartilage defects. Sci Transl Med (2021) Under revision *Equally contributing authors

3.     Power L, Acevedo L, Yamashita R, Rubin D, Martin I, Barbero A. Deep learning enables the automation of grading histological tissue engineered cartilage images for qulity control standardization. Osteoarthritis Cartilage (2021) In press,

4.     Duverney C, Abbasi H, Berkelaar M, Pelttari K, Cattin CP, Barbero A, Zan A, Reuter G. Sterile tissue ablation using laser light-system design, experimental validation, and outlook on clinical applicability.  ASME Journal (2020) In press,

5.     Chawia S, Berkelaar MHM, Dasen B, Halleux C, Guth-Gundler S, Kramer I, Ghosh S, Martin I*, Barbero A*, Occhetta P*. Blockage of bone morphogenetic protein signalling counteracts hyperthrophy in a human osteoarthritic micro-cartilage model. J Cell Scie 133(23):jcs249094 doi: 10.1242/jcs.249094 (2020) *corresponding authors

6.     Gu Y, Schwarz B, Forget A, Barbero A, Martin I, Shastri VP. Advanced bioink for 3D bioprinting of complex free-standing structures with high stiffness. Bioengineering 7:141 (2020)

7.     Ziadlou R, Rotman S, Teuschl A, Salzer E, Barbero A, Martin I, Alini M, Eglin D, Grad S. Optimimization of hyaluronic acid-tyramine/silk-fibroin composite hydrogels for cartilage tissue engineering and delivery of anti-inflammatory and anabolic drugs. Mater Sci Eng C (2020)

8.     Acevedo L, Iselin L, Berkelaar MHM, Salzmann GM, Wolf F, Feliciano S, Vogel N, Pagenstert G, Martin I, Pelttari K, Barbero A*, Arnold MP. Comparison of human articular cartilage tissue and chondrocytes isolated from peripheral versus central regions of traumatic lesions. Cartilage (2020) doi: 10.1177/1947603520958154 Online ahead of print

9.     Power LJ, Fasolato C, Barbero A, Wendt DJ, Wixmerten A, Martin I, Asnaghi MA. Sensing tissue engineered cartilage quality with Raman spectroscopy and statistical learning for the development of advanced characterization assays. Biosensors and Bioelectronics 166: 112467 (2020)

10.   Ziadlou R, Barbero A, Martin I, Wang X, Qin L, Alini M, Grad S. Anti-inflammatory and chondroprotective effects of vanillic acid and epimedin C in human osteoarthritic chondrocytes. Biomolecules 10: 932 (2020). 

11.   Asnaghi MA, Power L, Barbero A, Haug M, Köppl R, Wendt D, Martin I. Biomarker signatures of quality for engineering nasal chondrocyte-derived cartilage. Front Bioeng Biotechnol 8 :283 (2020).

12.   Lehoczky G, Wolf F, Mumme M, Gehmert S, Miot S, Haug M, Jakob M, Martin I, Barbero A. Intra-individual comparison of human nasal chondrocytes and debrided knee chondrocytes: relevance for engineering autologous cartilage grafts. Clin Hemorheol Microcirc 74: 67-78 (2020).

13.   Ziadlou R, Barbero A, Stoddart MJ, Wirth M, Li Z, Martin I, Wang X, Alini M, Grad S. Regulation of inflammatory response in human osteoarthritic chondrocytes by novel herbal small molecules. Int J Mol Sci 20: 5745 (2019). 

14.   Occhetta P, Mainardi A, Votta E, Vallmajo-Martin Q, Ehrbar M, Martin I, Barbero A*, Rasponi M. Hyper-physiological compression triggers osteoarthritic features in a cartilage-on-chip model. Nat Biomed Eng 3: 545-557 (2019). *corresponding author

15.   Gay MHP, Mehrkens A, Rittmann M, Haug, Barbero A*, Martin I, Schaeren S.  Nose to back: nasal chondrocytes are a potential autologous cell-transplant source for cell therapy based treatment of degenerative disc disease. Eur Cell Mater 22: 214-232(2019). *corresponding author

16.   Haeni DL, Lafosse T, Haggerty C, Plath J, Kida Y, Sanchez-Brass M, Wolf F, Calvo E, Müller A, Barbero A, Lafosse L. Tissue on the transferred coracoid graft after Latarjet procedure: histological and morphological findings. Am J Sports Med 47: 704-712 (2019).

17.   Stuedle C, Occhetta P, Geier F, Mehrkens A, Barbero A, Martin I. Challenges towards the identification of predictive markers for human mesenchymal stromal cells chondrogenic potential. Stem Cells Transl Med 8: 194-204(2019).

18.   Sarem M, Heizmann M, Barbero A, Martin I, Shastri VP. Hyper-stimulation of CaSR in human MSCs by biomimetic apatite inhibits endochondral ossification via temporal down regulation of PTH1R. Proc Natl Acad Sci USA 115:E6135-E6144 (2018).

19.   Occhetta P, Pigeot S, Rasponi M, Dasena B, Mehrkens A, Ullrich T, Kramer I, Guth-Gundel S, Barbero A, Martin I, Developmentally inspired programming of adult human mesenchymal stromal cells towards stable chondrogenesis. Proc Natl Acad Sci USA 115: 4625-4630 (2018).

20.   Stuedle C, Vallmajo-Martin Q, Haumer A, Guerrero J, Centola M, Mehrkens A, Schaefer DJ, Ehrbar M, Barbero A, Matin I.  Spatially confined induction of endochondral ossification by functionalized hydrogels for ectopic engineering of osteochondral tissues. Biomaterials 171: 219-229 (2018).

21.   Sarem M, Arya N, Heizmann M, Neffe AT, Barbero A, Gebauer TP, Martin I, Lendlein A, Shastri VP. Interplay between stiffness and degradation of architectured gelatin hydrogels leads to differentiatial modulation of chondrogenesis in vitro and in vivo. Acta Biomater 69: 83-94 (2018).

22.   Medeiros Da Cunha CM, Perugini V, Bernegger P, Centola M, Barbero A, Guildford AL, Santin M, Banfi A, Martin I, Marsano A. VEGF sequestration enhances in vivo cartilage formation. Int J Mol Sci 18, 2478; doi:10.3390/ijms18112478 (2017). 

23.   Burger MG, Steinitz A, Geurts J, Pippinger BE, Schaefer DJ, Martin I, Barbero A*, Pelttari K. Ascorbic acid attenuates senescence of human osteoarthritic osteoblasts. Int J Mol Sci 18, E2517 (2017) *corresponding author.

24.   Marmotti A, Mattia S, Castoldi F, Barbero A, Mangiavini L, Bonasia DE, Bruzzone M, Dettoni F, Scurati R and Peretti GM. Allogeneic umbilical cord-derived mesenchymal stem cells as a potential source for cartilage and bone regeneration: an in vitro study. Stem Cell Int 2017:1732094; doi: 10.1155/2017/1732094 (2017).

25.   Nusspaumer G, Jaiswal S, Barbero A, Reinhardt R, D.A. Ronen, Haumer A, Lufkin T, Martin I, Zeller R. Ontogenic identification and analysis of mesenchymal stromal cell populations during mouse limb and long bone development. Stem Cell Reports 9:1-15 (2017).

26.   Todorov A, Scotti C, Barbero A, Scherberich A, Papadimitropoulos A, Martin I. Monocytes seeded on engineered hypertrophic cartilage do not enhance endochondral ossification capacity. Tissue Eng Part A 23: 708-715 (2017).

27.   Manferdini C, Paolella F, Gabusi E, Gambari L, Filardo G, Fleury-Cappellesso, Barbero A, Murphy M, Lisignoli G. Switching of a M1 inflammatory macrophages subsets by adipose stromal cells contributes to resolution of osteoarthritic synovial tissue inflammation. Osteoarthritis Cartilage 25: 1161-1171 (2017).

28.   Mumme M*, Barbero A*, Miot S, Wixmerten A, Feliciano S, Wolf F, Asnaghi MA, Baumhoer D, Bieri O, Kretzschmar M, Pagenstert G, Haug M, Schaefer DJ, Martin I, Jakob M. Nasal chondrocytes-based engineered autologous cartilage tissue for the repair of articular cartilage defect: an observational first-in-human trial. Lancet 388: 337-346 (2016). *equal contributors

29.   Mumme M, Steinitz A, Nuss K, Klein K, Feliciano S, Kronen P, Jakob M, von Rechenberg B, Martin I, Barbero A, Pelttari K. Regenerative potential of tissue engineered nasal chondrocytes in got articular cartilage defects. Tissue Eng Part A 22: 1286-1295 (2016).

30.   Marsano A, Medeiros da Cunha CM, Ghanaati S, Gueven S, Centola M, Tsaryk R, Barbeck M, Stuedle C, Barbero A, Helmrich U, Schaeren S, Kirkpatrick JC, Banfi A, Martin I. Spontaneous in vivo chondrogenesis of bone marrow-derived mesenchymal progenitor cells by blocking Vascular Endothelial Growth Factor signaling. Stem Cells Transl Med 5: 1730-1738 (2016).

31.   Todorov A, Kreutz M, Haumer A, Scotti C, Barbero A, Bourgine PE, Scherberich A. Jaquiery C, Martin I, Fat-derived stromal vascular fraction cells enhance the bone-forming capacity of devitalized engineered hypertrophic cartilage matrix Stem Cell Trans Med 5: 1684-1694 (2016).

32.   Osinga R, di Maggio N, Todorov A, Allafi N, Barbero A, Laurent F, Schaere DJ, Martin I, Scherberich A. Generation of a bone organ by human adipose-derived stromal cells through endochondral ossification Stem Cell Trans Med 5: 1090-1097 (2016).

33.   Müller S, Acevedo L, Wang X, Karim MZ, Matta A, Mehrkens A, Schaeren S, Feliciano S, Jakob M, Martin I, Barbero A*, Erwin MW*.  Notochordal cell conditioned medium (NCCM) regenerates end-stage human osteoarthritic articular chondrocytes and promotes a healthy phenotype. Arthritis Res Ther 18:125 (2016). *equal contributors

34.   Pelttari K, Barbero A, Martin I. A potential role of homeobox transcription factors in osteoarthritis Ann Transl Med 3: 1-5 (2015).

35.   Sabatino MA, Santoro R, Gueven S, Jaquiery C, Wendt DJ, Martin I, Moretti M, Barbero A. Cartilage graft engineering by co-culturing primary articular chondrocytes with bone marrow stromal cells. J Tissue Eng Regen Med 9: 1394-1403 (2015).

36.   Barandun M, Iselin LD, Santini F, Pansini M, Scotti C, Baumhoer D, Bieri O, Studler U, Wirz D, HaugM, Jakob M, Schaefer DJ, Martin I, Barbero A. Generation and characterization of osteochondral grafts with human nasal chondrocytes. J Orthop Res 33: 1111-1119 (2015).

37.   Bocelli-Tyndall C, Trella E, Frachet A, Zajac P, Pfaff D, Geurts J, Heiler S, Barbero A, Mumme M, Resink TJ, Schaeren S, Spagnoli GC, Tyndall A. FGF2 induces RANKL gene expression as well as IL1β regulated MHC class II in human bone marrow-derived mesenchymal progenitor stromal cells. Ann Rheum Dis 74: 260-266 (2015).

38.   Sesia SB, Duhr R, Madeiros da Cunha C, Todorov A, Schaeren S, Padovan E, Spagnoli G, Martin I, Barbero A. Anti-inflammatory/tissue repair macrophages enhances the cartilage-forming capacity of human bone marrow-derived mesenchymal stromal cells. J Cell Physiol 230: 1258–1269 (2015).

39.   Pippenger BE, Ventura M, Pelttari K, Feliciano S, Jaquiery C, Scherberich A, Walboomers XF, Barbero A, Martin I. Bone forming capacity of adult human nasal chondrocytes. J Cell Mol Med 19:1390-1399 (2015)

40.   Centola M, Tonnarelli B, Hendriks J, van den Doel M, de Jong WC, Feliciano S, Papadimitropolous A, Piccinini E, Geurts J, Martin I, Barbero A. An improved cartilage digestion method for research and clinical applications. Tissue Eng Part A 21: 394-403 (2015).

41.   Pelttari K, Pippenger B, Mumme M, Feliciano S, Scotti C, Mainil-Varlet P, Procino A, von Rechenberg B, Schwamborn T, Jakob M, Cillo C, Barbero A, Martin I. Adult human neural crest-derived cells for articular cartilage repair. Sci Transl Med 6: 251, 251ra119 (2014).

42.   Papadimitropoulos A, Piccinini E, Brachat S, Braccini A, Wendt D, Barbero A, Jacobi C, Martin I. Expansion of human mesenchymal stromal cells from fresh bone marrow in a 3D scaffold-based system under direct perfusion. PLoS One 9(7): e102359 (2014).

43.   Fulco I, Miot S, Haug MD, Barbero A, Wixmerten A, Feliciano S, Wolf F, Jundt G, Marsano A, Farhadi J, Heberer M, Jakob M, Schaefer DJ, Martin I. Engineered autologous cartilage tissue for nasal reconstruction after tumour resection: an observational first-in-human trial. Lancet 384: 337-346(2014).

44.   Peñuela L, Wolf F, Raiteri R, Wendt D, Martin I, Barbero A. Atomic force microscopy to investigate spatial patterns of response to IL-1b in engineered cartilage tissue elasticity. Journal of Biomechanics 47:9 2157-2164 (2014).

45.   Centola M, Tonnarelli B, Schaeren S, Glaser N, Barbero A, Martin I. Priming 3D cultures of human mesenchymal stromal cells towards cartilage formation via developmental pathways Stem Cells Dev 22: 2849-2858 (2013).

46.   Centola M, Abbruzzese F, Scotti C, Barbero A, Vadalà G, Denaro V, Martin I, Trombetta M, Rainer A, Marsano A. Scaffold-based delivery of a clinically-relevant anti-angiogenic drug promotes the formation of in vivo stable cartilage. Tissue Eng Part A 19: 1960-1971 (2013).

47.   Scotti C, Piccinini E, Takizawa H, Todorov A, Bourgine P, Papadimitropoulos A, Barbero A, Manz MG, Martin I. Engineering of a functional bone organ through endochondral ossification Proc Natl Acad Sci USA 110: 3997-4002 (2013).

48.   Mumme M, Scotti C, Papadimitropoulos A, Todorov A, Hoffmann W, Bocelli-Tyndall C, Jakob M, Wendt D, Martin I, Barbero A. Interleukin-1beta modulates endochondral ossification by human adult bone marrow stromal cells. Eur Cell Mater 24: 224-236(2012).

49.   Vonwil D, Trüssel A, Haupt O, Gobaa S, Barbero A, Shastri P, Martin I. Substrate elasticity modulates TGF beta stimulated re-differentiation of expanded human articular chondrocytes. Drug Deliv and Transl Res 2: 351-362 (2012).

50.   Acharya A, Adesida A, Zajac P, Mumme M, Riesle J, Martin I, Barbero A. Enhanced chondrocyte proliferation and mesenchymal stromal cells chondrogenesis in coculture pellets mediate improved cartilage formation. J Cell Phisiol. 227: 88-97 (2012).

51.   Scotti C, Osmokrovic A, Wolf F, Miot S, Peretti GM, Barbero A, Martin I. Response of human engineered cartilage based on articular or nasal chondroctes to IL-1b and low oxygen. Tissue Eng Part A. 18: 362-372 (2012).

52.   Francioli SE, Cavallo C, Grigolo B, Martin I, Barbero A. Engineered cartilage maturation regulates cytokine production and interleukin-1b response. Clin Orthop Relat Res. 469: 2773-2784 (2011).

53.   Grote M, Palumberi V, Wagner B, Barbero A, Martin I. Dynamic Formation of Oriented Patches in Chondrocyte Cell Cultures. J Math Biol. 63: 757–777 (2011).

54.   Vonwil D, Schuler M, Barbero A, Stroebel S, Wendt D, Textor M, Aebi U, Martin I. RGD-peptide restricted interactions with a protein-resistant substrate are sufficient for human articular chondrocyte adhesion, growth and maintenance of cartilage forming capacity. Eur Cell Mater. 20:316-328 (2010).

55.   Bocelli-Tyndall C, Zajac P, Di Maggio N, Trella E, Benvenuto F, Iezzi G, Scherberich A, Barbero A, Schaeren S, Pistoia V, Spagnoli G, Vukcevic M, Martin I, Tyndall A. Fibroblast Growth Factor 2 and Platelet-Derived Growth Factor, but not Platelet Lysate, induce proliferation dependent functional Class II Major Histocompatibility Complex Antigen in human mesenchymal stem cells. Arthritis Rheum 62: 3815-3825 (2010).

56.   Francioli SE, Candrian C, Martin K, Heberer M, Martin I, Barbero A Effect of three-dimensional expansion and cell seeding density on the cartilage-forming capacity of human articular chondrocytes in type II collagen sponges. J Biomed Mater Res A 95: 924-931 (2010).

57.   Candrian C, Miot S, Wolf F, Bonacina E, Dickinson S, Wirz D, Jakob M, Valderrabano V, Barbero A, Martin I. Are ankle chondrocytes from damaged fragments a suitable cell source for cartilage repair? Osteoarthritis Cartilage 18:1067-1076 (2010).

58.   Scotti S, Tonnarelli B, Papadimitropoulos A, Scherberich A, Schaeren S, Schauerte A, Lopez-Rios J, Zeller R, Barbero A*, Martin I*. Recapitulation of endochondral bone formation using human mesenchymal stem cells as a paradigm for developmental engineering. Proc Natl Acad Sci USA 107: 7251-7256 (2010). *equal contributors

59.   Stroebel S, Loparic M, Wendt D, Schenk AD, Candrian C, Lindberg RL, Moldovan F, Barbero A, Martin I. Anabolic and catabolic responses of human artiular chondrocytes to varying oxygen percentages. Arthritis Res Ther 12: R34 (2010).

60.   Scotti S, Wirz D, Wolf F, Schaefer DJ, Bürgin V, Daniels AU, Valderrabano V, Candrian C, Jakob M, Martin I, Barbero A. Engineering human cell-based, functionally integrated osteochondral grafts by biological bonding of engineered cartilage tissues to bony scaffolds. Biomaterials 31: 2252-2259 (2010).

61.   Miot S, Gianni-Barrera R, Pelttari K, Acharya C, Pierre Mainil-Varlet, P, Juelke H, Jaquiéry C, Candrian C, Barbero A, Martin I. In vitro and in vivo validation of human and goat chondrocyte labeling by GFP lentivirus transduction Tissue Eng Part C Methods 16: 11-21 (2010).

62.   Schaeren S, Jaquiéry C, Wolf F, Papadimitropoulos A, Barbero A, Schultz-Thater E, Heberer M, Martin I. Effect of bone sialoprotein coating of ceramic and synthetic polymer materials on in vitro osteogenic cell differentiation and in vivo bone formation. J Biomed Mater Res A92: 1461-1467 (2009).

63.   Candrian C, Barbero A, Bonacina E, Francioli S, Hirschmann M, Milz S, Valderrabano V, Heberer M, Martin I, Jakob M. A novel implantation technique for engineered osteo-chondral grafts. Knee Surg Sports Traumatol Arthrosc 17: 1377-1383 (2009).

64.   Candrian C, Bonacina E, Frueh JA, Vonwil D, Dickinson S, Wirz D, Heberer M, Jakob M, Martin I, Barbero A. Intra-individual comparison of human ankle and knee chondrocytes in vitro: relevance for talar cartilage repair Osteoarthritis Cartilage 17: 489-96 (2009).

65.   Bocelli-Tyndall C, Bracci L, Schaeren S, Feder-Mengus C, Barbero A, Tyndall A, Spagnoli GC. Human bone marrow mesenchymal stem cells and chondrocytes promote and/or suppress the in vitro proliferation of lymphocytes stimulated with the cytokines IL 2, IL 7 and IL 15. Ann of Rheum Dis 68:1352-1359 (2009).

66.   Wolf F, Candrian C, Wendt D, Farhadi J, Heberer M, Martin I, Barbero A. Cartilage tissue engineering using pre-aggregated human articular chondrocytes. Eur Cell Mater 16: 92-99 (2008).

67.   Candrian C, Vonwil D, Barbero A, Bonacina E, Miot S, Farhadi J, Wirz D, Dickinson S, Hollander A, Jakob M, Li Z, Alini M, Heberer M, Martin I. Engineered cartilage by nasal chondrocytes is responsive to physical forces resembling joint loading. Arthritis Rheum 58: 197-208 (2008).

68.   Wolf F, Haug M, Farhadi J, Candrian C, Martin I, Barbero A. A low percentage of autologous serum can replace bovine serum to engineer human nasal cartilage. Eur Cell Mater 15: 1-10 (2007).

69.   Francioli SE, Martin I, Sie CP, Hagg R, Tommasini R, Candrian C, Heberer M, Barbero A. Growth factors for clinical-scale expansion of human articular chondrocytes: relevance for automated bioreactor systems. Tissue Engineering 13: 1227-1234 (2007).

70.   Grogan SP*, Barbero A*, Diaz-Romero J, Cleton-Jansen AM, Soeder S, Whiteside R, Hogendoorn P, Farhadi J, Aigner T, Martin I, Mainil-Varlet P. Identification of markers to characterize and sort human articular chondrocytes with enhanced in vitro chondrogenic capacity. Arthritis Rheum 56: 586-595 (2007). *equal contributors

71.   Sebok D, Eberhard M, Barbero A, Linscheid P, Timper K, Martin I, Keller U, Muller B, Zulewski H. Bone marrow derived mesenchymal stem cells isolated from patient with diabetes mellitus type 1 are able to induce pancreatic endocrine genes in vitro. J Stem Cells Regen Med 16: 102-103 (2007).

72.   Grogan SP, Barbero A, Winkelmann V, Rieser F, Fitzsimmons JS, O’Driscoll S, Martin I, Mainil-Varlet P. Visual histological grading system for the evaluation of in vitro-generated neocartilage. Tissue Engineering 12: 2141-2149 (2006).

73.   Bocelli-Tyndall, Barbero A, Candrian C, Ceredig R, Tyndall A, Martin I. Human articular chondrocytes suppress in vitro proliferation of anti-CD3 activated peripheral blood mononuclear cells. J Cell Physiol 209:732-734 (2006).

74.   Erberhardt M, Salmon P, von Mach MA, Hengstler JG, Brulport M, Linscheid P, Seboek D, Oberhlzer J, Barbero A, Martin I, Muller B, Trono D, Zulewski H. Multipotent nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets. Biochem Biophys Res Commun 345: 1167-1176 (2006).

75.   Barbero A, Grogan SP, Mainil-Varlet P, Martin I. Expansion on specific substrates regulates the phenotype and differentiation capacity of human articular chondrocytes. J Cell Biochem 98: 1140-1149 (2006).

76.   Barbero A, Palumberi V, Wagner B, Sader R, Grote MJ, Martin I. Experimental and mathematical study of the influence of growth factors on the growth kinetics of adult human articular chondrocytes. J Cell Physiol 204: 830-838 (2005).

77.   Farhadi J, Jaquery C, Barbero A, Jakob M, Schaeren S, Pierer G, Heberer M, Martin I. Differentiation-dependent upregulation of BMP-2; TGFb-1 and VEGF expression by FGF-2 in human bone marrow stromal cells. Plast Reconstr Surg 116: 1379-1386 (2005).

78.   Barbero A, Grogan S, Schafer D, Heberer M, Mainil-Varlet P, Martin I. Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity. Osteoarthritis Cartilage 12: 476-484 (2004).

79.   Barbero A, Ploegert S, Heberer M, Martin I. Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes. Arthritis Rheum 48: 1315-1325 (2003)

80.   Frank O, Heim M, Jakob M, Barbero A, Schafer D, Bendik I, Dick W, Heberer M, Martin I. Real-time quantitative RT-PCR analysis of human bone marrow stromal cells during osteogenic differentiation in vitro. Cell Biochem; 85: 737-746 (2002).

81.   Barbero A, Benelli R, Minghelli S, Tosetti F, Dorcaratto A, Ponzetto C, Wernig A, Cullen MJ, Albini A, Noonan DM. Growth factor supplemented matrigel improves ectopic skeletal muscle formation--a cell therapy approach. J Cell Physiol 186: 183-192 (2001).

82.   Benelli R, Barbero A, Ferrini S, Scapini P, Cassatella M, Bussolino F, Tacchetti C, Noonan DM, Albini A. Human immunodeficiency virus transactivator protein (Tat) stimulates chemotaxis, calcium mobilization, and activation of human polymorphonuclear leukocytes: implications for Tat-mediated pathogenesis. J Infect Dis 182: 1643-1651 (2000).

83.   Benelli R, Barbero A, Buffa A, Aluigi MG, Masiello L, Morbidelli L, Ziche M, Albini A, Noonan D. Distinct chemotactic and angiogenic activities of peptides derived from Kaposi's sarcoma virus encoded chemokines. Int J Oncol 17: 75-81 (2000).


1.       Mumme M, Wixmerten A, Miot S, Barbero A, Kaempfen A, Saxer F, Gehmert S, Krieg A, Schaefer DJ, Jakob M, Martin I. Tissue Engineering for pediatric patients. Swiss Med Wkly 149:w20032 (2019).

2.       Pelttari K, Mumme M, Barbero A, Martin I. Nasal chondrocytes as a neural crest-derived cell source for regenerative medicine. Curr Opin Biotechnol. 47: 1-6 (2017).

3.       Occhetta P, Stüdle C, Barbero A, Martin I. Learn, simplify and implement: developmental re-engineering strategies for cartilage repair. Swiss Med Wkly. 146: w14346 (2016).

4.       Bhattacharjee M, Coburn J, Centola M, Murab S, Barbero A, Kaplan DL, Martin I, Ghosh S. Tissue engineering strategies to study cartilage development, degeneration and regeneration. Adv Drug Deliv Rev 84: 107-122 (2015).

5.       Tonnarelli B, Centola M, Barbero A, Zeller R, Martin I. Re-Engineering Development to Instruct Tissue Regeneration. Curr Top Dev Biol. 108: 319-338 (2014).

6.       Scotti C, Leumann A, Candrian C, Barbero A, Croci D, Schaefer DJ, Jakob M, Valderrabano V, Martin I. Autologous tissue-engineered osteochondral graft for talus osteochondral lesions: state of the art and future perspectives. Techniques in Foot & Ankle Surgery. 10: 163-168 (2011).

7.       Martin I, Miot S, Barbero A, Jakob M, Wendt D. Osteochondral tissue engineering. J Biomech 40: 750-765 (2007).

Book chapters 

1.        Van Osch GJVM, Barbero A. Brittberg M, Correa D, Diederichs S, Goldring MB, Hardingham T, Jenner F, Narcisi R, Randolph MA, Nuernberger S. In J.M. et al. (eds.), Cell Engineering and Regeneration Springer Springer International Publishing AG 2018.

2.        Scotti C, Tonnarelli B, Papadimitropoulos A, Piccinini E, Todorov A, Centola M, Barbero A, Martin I. Engineering small-scale and scaffold-based bone organs via endochondral ossification using adult progenitor cells. In M. Gnecchi (ed.), Mesenchymal Stem Cells: Methods and Protocols, Methods in Molecular Biology Springer Science+Business Media New York 1416:413-424 (2016).

3.        Barbero A, Martin I. Human articular chondrocyte culture. In AP. Hollander, PV. Hatton.  Methods in Molecular Medicine –Tissue Engineering 2nd Edition Humana Press, Totowa, NJ 140:237-247 (2007).

4.        Martin I, Barbero A, Jakob M, Miot S, Wendt D. Fabrication of cartilage-bone constructs for osteochondral repair. In: S. Zanasi, M. Brittberg, M. Marcacci (eds.), Basic Science, Clinical Repair and Reconstruction of Articular Cartilage Defects: Current Status and Prospects. Timeo Editore, Bologna (Italy) 109:1013-1025 (2006).