Selected Publications

1. Beltra, J.C., Abdel-Hakeem, M.S., Manne, S., Zhang, Z., Huang, H., Kurachi, M., Su, L., Picton, L., Ngiow, S.F., Muroyama, Y., et al. (2023). Stat5 opposes the transcription factor Tox and rewires exhausted CD8(+) T cells toward durable effector-like states during chronic antigen exposure. Immunity 56, 2699-2718 e2611. 10.1016/j.immuni.2023.11.005.

2. Qiu, J., Xu, B., Ye, D., Ren, D., Wang, S., Benci, J.L., Xu, Y., Ishwaran, H., Beltra, J.C., Wherry, E.J., et al. (2023). Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction. Nat Cancer. 10.1038/s43018-022-00490-y.

3. Lewis, E.L., Xu, R., Beltra, J.C., Ngiow, S.F., Cohen, J., Telange, R., Crane, A., Sawinski, D., Wherry, E.J., and Porrett, P.M. (2022). NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med 219. 10.1084/jem.20201599.

4. Abdel-Hakeem, M.S., Manne, S., Beltra, J.C., Stelekati, E., Chen, Z., Nzingha, K., Ali, M.A., Johnson, J.L., Giles, J.R., Mathew, D., et al. (2021). Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Nat Immunol 22, 1008-1019. 10.1038/s41590-021-00975-5.

5. Johnnidis, J.B., Muroyama, Y., Ngiow, S.F., Chen, Z., Manne, S., Cai, Z., Song, S., Platt, J.M., Schenkel, J.M., Abdel-Hakeem, M., et al. (2021). Inhibitory signaling sustains a distinct early memory CD8(+) T cell precursor that is resistant to DNA damage. Sci Immunol 6. 10.1126/sciimmunol.abe3702.

6. Beltra, J.C., Manne, S., Abdel-Hakeem, M.S., Kurachi, M., Giles, J.R., Chen, Z., Casella, V., Ngiow, S.F., Khan, O., Huang, Y.J., et al. (2020). Developmental Relationships of Four Exhausted CD8(+) T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms. Immunity 52, 825-841 e828. 10.1016/j.immuni.2020.04.014.

7. Chen, Z., Ji, Z., Ngiow, S.F., Manne, S., Cai, Z., Huang, A.C., Johnson, J., Staupe, R.P., Bengsch, B., Xu, C., et al. (2019). TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision. Immunity 51, 840-855 e845. 10.1016/j.immuni.2019.09.013.

8. Shourian, M., Beltra, J.C., Bourdin, B., and Decaluwe, H. (2019). Common gamma chain cytokines and CD8 T cells in cancer. Semin Immunol 42, 101307. 10.1016/j.smim.2019.101307.

9. Beltra, J.C., Bourbonnais, S., Bedard, N., Charpentier, T., Boulange, M., Michaud, E., Boufaied, I., Bruneau, J., Shoukry, N.H., Lamarre, A., and Decaluwe, H. (2016). IL2Rbeta-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection. Proc Natl Acad Sci U S A 113, E5444-5453. 10.1073/pnas.1604256113.

10. Beltra, J.C., and Decaluwe, H. (2016). Cytokines and persistent viral infections. Cytokine 82, 4-15. 10.1016/j.cyto.2016.02.006.