Selected Publications

Harris, S.S., Rajani, R.M., Zünkler, J., Ellingford, R., Yang, M., Rowland, J.M., Schmidt, A., Lee, B.I., Kehring, M., Hellmuth, M., et al. (2025). The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo. Cell Rep. 44, 115801. https://doi.org/10.1016/j.celrep.2025.115801.

Papanikolaou, A., Graykowski, D., Lee, B.I., Yang, M., Ellingford, R., Zünkler, J., Bond, S.A., Rowland, J.M., Rajani, R.M., Harris, S.S., et al. (2025). Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo. Neuron. https://doi.org/10.1016/j.neuron.2025.04.010

Harris, S.S., Ellingford, R., Hartmann, J., Dasgupta, D., Kehring, M., Rajani, R.M., Graykowski, D., Quittot, N., Sivasankaran, D., Commins, C., et al. (2025). Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons. Cell. https://doi.org/10.1016/j.cell.2025.04.006

Rajani, R.M., Ellingford, R., Hellmuth, M., Harris, S.S., Taso, O.S., Graykowski, D., Lam, F.K.W., Arber, C., Fertan, E., Danial, J.S.H., et al. (2024). Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease. PLoS Biol. 22, e3002727. https://doi.org/10.1371/journal.pbio.3002727

Milioto, C., Carcolé, M., Giblin, A., Coneys, R., Attrebi, O., Ahmed, M., Harris, S.S., Lee, B.I., Yang, M., Ellingford, R.A., et al. (2024). PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nat. Neurosci. 27, 643–655. https://doi.org/10.1038/s41593-024-01589-4 

Busche, M.A., and Hyman, B.T. (2020). Synergy between amyloid-β and tau in Alzheimer’s disease. Nat. Neurosci. 23, 1183–1193. https://doi.org/10.1038/s41593-020-0687-6

Harris, S.S., Wolf, F., De Strooper, B., and Busche, M.A. (2020). Tipping the scales: Peptide-dependent dysregulation of neural circuit dynamics in Alzheimer’s disease. Neuron 107, 417–435. https://doi.org/10.1016/j.neuron.2020.06.005

Busche, M.A., Wegmann, S., Dujardin, S., Commins, C., Schiantarelli, J., Klickstein, N., Kamath, T.V., Carlson, G.A., Nelken, I., and Hyman, B.T. (2019). Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nat. Neurosci. 22, 57–64. https://doi.org/10.1038/s41593-018-0289-8

Keskin, A.D., Kekuš, M., Adelsberger, H., Neumann, U., Shimshek, D.R., Song, B., Zott, B., Peng, T., Förstl, H., Staufenbiel, M., et al. (2017). BACE inhibition-dependent repair of Alzheimer’s pathophysiology. Proc. Natl. Acad. Sci. U. S. A. 114, 8631–8636. https://doi.org/10.1073/pnas.1708106114

Busche, M.A., Kekuš, M., Adelsberger, H., Noda, T., Förstl, H., Nelken, I., and Konnerth, A. (2015). Rescue of long-range circuit dysfunction in Alzheimer’s disease models. Nat. Neurosci. 18, 1623–1630. https://doi.org/10.1038/nn.4137

Willem, M., Tahirovic, S., Busche, M.A., Ovsepian, S.V., Chafai, M., Kootar, S., Hornburg, D., Evans, L.D., Moore, S., Daria, A., et al. (2015). η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature 526, 443–447. https://doi.org/10.1038/nature14864 

Busche, M.A., Chen, X., Henning, H.A., Reichwald, J., Staufenbiel, M., Sakmann, B., and Konnerth, A. (2012). Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease. Proc. Natl. Acad. Sci. U. S. A. 109, 8740–8745. https://doi.org/10.1073/pnas.1206171109

Busche, M.A., Eichhoff, G., Adelsberger, H., Abramowski, D., Wiederhold, K.-H., Haass, C., Staufenbiel, M., Konnerth, A., and Garaschuk, O. (2008). Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer’s disease. Science 321, 1686–1689. https://doi.org/10.1126/science.1162844

 

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