Serum neurofilament light chain reference database for individual application in paediatric care: a retrospective modelling and validation study. Abdelhak A, Petermeier F, Benkert P, Schädelin S, Oechtering J, Maleska Maceski A, Kabesch M, Geis T, Laub O, Leipold G, Gobbi C, Zecca C, Green A, Tumani H, Willemse E, Wiendl H, Granziera C, Kappos L, Leppert D, Waubant E, Wellmann A, Kuhle J. (2023): The Lancet Neurology, ahead of print

Development and multi-center validation of a fully automated digital immunoassay for neurofilament light chain: Toward a clinical blood test for neuronal injury. Wilson D, Chan D, Chang L, Mathis R, Verberk I, Montalban X, Comabella M, Fissolo N, Bielekova B, Masvekar R, Chitnis T, Ziemssen T, Akgün K, Blennow K, Zetterberg H, Brück W, Giovannoni G, Gnanapavan S, Bittner S, Zipp F, Comi G, Furlan R, Lehmann S, Thebault S, Freedman M, Bar-Or A, Kramer M, Otto M, Halbgebauer S, Hrusovsky K, Plavina T, Khalil M, Piehl F, Wiendl H, Kappos L, Maceski A, Willemse E, Leppert D, Teunissen C, Kuhle J. (2023): Clin Chem Lab Med, ahead of print

Granulocyte activation markers in cerebrospinal fluid differentiate acute neuromyelitis spectrum disorder from multiple sclerosis. Leppert D, Watanabe M, Schaedelin S, Piehl F, Furlan R, Gastaldi M, Lambert J, Evertsson E, Fink K, Matsushita T, Masaki K, Isobe N, Jun-ichi K, Benkert P, Maceski A, Willemse E, Oechtering J, Orleth A, Meier S, Kuhle J (2023): Journal of Neurology, Neurosurgery, and Psychiatry, ahead of print

Serum glial fibrillary acidic protein compared with neurofilament light chain as a biomarker for disease progression in multiple sclerosis. Meier S, Willemse EAJ, Schaedelin S, Oechtering J, Lorscheider J, Melie-Garcia L, Cagol A, Barakovic M, Galbusera R, Subramaniam S, Barro C, Abdelhak A, Thebault S, Achtnichts L, Lalive P, Müller S, Pot C, Salmen A, Disanto G, Zecca C, D'Souza M, Orleth A, Khalil M, Buchmann A, Du Pasquier R, Yaldizli Ö, Derfuss T, Berger K, Hermesdorf M, Wiendl H, Piehl F, Battaglini M, Fischer U, Kappos L, Gobbi C, Granziera C, Bridel C, Leppert D, Maleska Maceski A, Benkert P, Kuhle J (2023): Jama Neurology, ahead of print

Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: A retrospective modelling and validation study. Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli Ö, Maceski A, Oechtering J, Achtnichts L, Conen D, Derfuss T, Lalive PH, Mueller C, Müller S, Naegelin Y, Oksenberg JR, Pot C, Salmen A, Willemse E, Kockum I, Blennow K, Zetterberg H, Gobbi C, Kappos L, Wiendl H, Berger K, Sormani MP, Granziera C, Piehl F, Leppert D, Kuhle J, for the NfL Reference Database in the Swiss Multiple Sclerosis Cohort Study Group (2022): The Lancet Neurology, 21,246-257 DOI: 10.1016/S1474-4422(22)00009-6

Intrathecal immunoglobulin M synthesis is an independent biomarker for higher disease activity and severity in multiple sclerosis. Oechtering J, Schaedelin S, Benkert P, Müller S, Achtnichts L, Vehoff J, Disanto G, Findling O, Fischer-Barnicol B, Orleth A, Chan A, Pot C, Barakovic M, Rahmanzadeh R, Galbusera R, Heijnen I, Lalive PH, Wuerfel J, Subramaniam S, Aeschbacher S, Conen D, Naegelin Y, Maceski A, Meier S, Berger K, Wiendl H, Lincke T, Lieb J, Yaldizli Ö, Sinnecker T, Derfuss T, Regeniter A, Zecca C, Gobbi C, Kappos L, Granziera C, Leppert D, Kuhle J, Swiss Multiple Sclerosis Cohort Study (2021): Annals of Neurology, 90,477-489 DOI: 10.1002/ana.26137

Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis. Barro C, Benkert P, Disanto G, Tsagkas C, Amann M, Naegelin Y, Leppert D, Gobbi C, Granziera C, Yaldizli Ö, Michalak Z, Wuerfel J, Kappos L, Parmar K, Kuhle J. (2018): Brain 141,2382–2391. DOI: 10.1093/brain/awy154

Antigen Extraction and B Cell Activation Enable Identification of Rare Mem-brane Antigen Specific Human B Cells. Zimmermann M, Rose N, Lindner JM, Kim H, Gonçalves AR, Callegari I, Syedbasha M, Kaufmann L, Egli A, Lindberg RLP, Kappos L, Traggiai E, Sanderson NSR, Derfuss T. (2019): Front. Immunol. 10, 829. DOI: 10.3389/fimmu.2019.00829

Association of Rituximab Treatment With Disability Progression Among Patients With Secondary Progressive Multiple Sclerosis. Naegelin Y, Naegelin P, von Felten S, Lorscheider J, Sonder J, Uitdehaag BMJ, Scotti B, Zecca C, Gobbi C, Kappos L, Derfuss T. (2019): JAMA Neurol. 76, 274–281. DOI: 10.1001/jamaneurol.2018.4239

Dimethyl fumarate influences innate and adaptive immunity in multiple sclerosis. Diebold M, Sievers C, Bantug G, Sanderson N, Kappos L, Kuhle J, Lindberg RLP, Derfuss T. (2018): J. Autoimmun. 86, 39–50. DOI: 10.1016/j.jaut.2017.09.009

Cocapture of cognate and bystander antigens can activate autoreactive B cells. Sanderson NS, Zimmermann M, Eilinger L, Gubser C, Schaeren-Wiemers N, Lindberg RL, Dougan SK, Ploegh HL, Kappos L, Derfuss, T. (2017): Proc. Natl. Acad. Sci. U SA. 114, 734–739. DOI: 10.1073/pnas.1614472114

Multiple Sclerosis and Antibodies against KIR4. Pröbstel AK, Kuhle J, Lecourt AC, Vock I, Sanderson NS, Kappos L, Derfuss T. (2016): N. Engl. J. Med. 374, 1496–1498. DOI: 10.1056/NEJMc1507131

Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities. Rose N, Holdermann S, Callegari I, Kim H, Fruh I, Kappos L, Kuhle J, Müller M, Sanderson NSR, Derfuss T. Acta Neuropathol. 2022 Nov;144(5):1005-1025. DOI: 10.1007/s00401-022-02493-6

High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis. Diebold M, Galli E, Kopf A, Sanderson NSR, Callegari I, Benkert P, Gonzalo Núñez N, Ingelfinger F, Herms S, Cichon S, Kappos L, Kuhle J, Becher B, Claassen M, Derfuss T. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2205042119. DOI: 10.1073/pnas.2205042119

Immunological Predictors of Dimethyl Fumarate-Induced Lymphopenia. Diebold M, Galli E, Kopf A, Sanderson N, Callegari I, Ingelfinger F, Núñez NG, Benkert P, Kappos L, Kuhle J, Becher B, Claassen M, Derfuss T. Ann Neurol. 2022 May;91(5):676-681. DOI: 10.1002/ana.26328

Mass Cytometry of CSF Identifies an MS-Associated B-cell Population. Johansson D, Rauld C, Roux J, Regairaz C, Galli E, Callegari I, Raad L, Waldt A, Cuttat R, Roma G, Diebold M, Becher B, Kuhle J, Derfuss T, Carballido JM, Sanderson NSR. Neurol Neuroimmunol Neuroinflamm. 2021 Feb 15;8(2):e943. DOI: 10.1212/NXI.0000000000000943

Association of Rituximab Treatment With Disability Progression Among Patients With Secondary Progressive Multiple Sclerosis. Naegelin Y, Naegelin P, von Felten S, Lorscheider J, Sonder J, Uitdehaag BMJ, Scotti B, Zecca C, Gobbi C, Kappos L, Derfuss T. (2019): JAMA Neurol. 76, 274–281. DOI: 10.1001/jamaneurol.2018.4239

Cocapture of cognate and bystander antigens can activate autoreactive B cells. Sanderson NS, Zimmermann M, Eilinger L, Gubser C, Schaeren-Wiemers N, Lindberg RL, Dougan SK, Ploegh HL, Kappos L, Derfuss, T. (2017): Proc. Natl. Acad. Sci. U SA. 114, 734–739. DOI: 10.1073/pnas.1614472114