Insulin . Diabetes . Obesity . IL-1 . IL-6 . Inflammasome
Immune-mediated response to nutrition in physiology and pathology
Our research aims at the understanding of the pathogenesis of type 2 diabetes. We could identify an inflammatory process underlying failure of insulin production in this disease. Thereby we could showed that metabolic stress induces an IL-1β mediated immune response. We confirmed our hypothesis in clinical studies showing that modulation of the immune system may improve metabolism in patients with type 2 diabetes. The work has contributed to the concept that the innate immune system is an integral component in the regulation of metabolism, i. e. immunometabolism.