Selected Publications

 

 

Grzejda, D., Hess, A., Rezansoff, A., Gorey, S., Carrasco, J., Alfonso-Gonzalez, C., Tsagkris, S., Neuhaus, L., Shi, M., Ozbulut, H.C., Vögtle, F.N., Vlachos, A., and Hilgers, V. (2025). Pumilio differentially binds to mRNA 3′ UTR isoforms to regulate localization of synaptic proteins. EMBO Reports 26, 1792-1815.

Alfonso-Gonzalez, C., and Hilgers, V. (2024). (Alternative) transcription start sites as regulators of RNA processing. Trends in Cell Biology 34, 1018-1028.

Alfonso-Gonzalez, C., Legnini, I., Holec, S., Arrigoni, L., Ozbulut, H.C., Mateos, F., Koppstein, D., Rybak-Wolf, A., Bönisch, U., Rajewsky, N., and Hilgers, V. (2023). Sites of transcription initiation drive mRNA isoform selection. Cell 186, 2438-2455.

Alfonso-Gonzalez, C., Arrigoni, L., Ozbulut, H.C., Falk, S., Bönisch, U., and Hilgers, V. (2023). Identification of regulatory links between transcription and RNA processing with long-read sequencing. STAR Protocols 4, 102505.

Carrasco, J., Mateos, F., and Hilgers, V. (2022). A critical developmental window for ELAV/Hu-dependent mRNA signatures at the onset of neuronal differentiation. Cell Reports 41, 111542.

Grzejda, D., Mach, J., Schweizer, J.A., Hummel, B., Rezansoff, A.M., Eggenhofer, F., Panhale, A., Lalioti, M.E., Cabezas Wallscheid, N., Backofen, R., Felsenberg, J., and Hilgers, V. (2022). The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity. Science Advances 8, eabo5578.

Carrasco, J., Rauer, M., Hummel, B., Grzejda, D., Alfonso-Gonzalez, C., Lee, Y., Wang, Q., Puchalska, M., Mittler, G., and Hilgers, V. (2020). ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue. Molecular Cell 80, 156-163.

Oktaba, K., Zhang, W., Lotz, T.S., Jun, D.J., Lemke, S.B., Ng, S.P., Esposito, E., Levine, M., and Hilgers, V. (2015). ELAV Links Paused Pol II to Alternative Polyadenylation in the Drosophila Nervous System. Molecular Cell 57, 341-348.

Hilgers, V., Lemke, S.B., and Levine, M. (2012). ELAV mediates 3′ UTR extension in the Drosophila nervous system. Genes & Development 26, 2259-2264.

Hilgers, V., Perry, M.W., Hendrix, D., Stark, A., Levine, M., and Haley, B. (2011). Neural-specific elongation of 3′ UTRs during Drosophila development. Proceedings of the National Academy of Sciences of the United States of America 108, 15864-15869.