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New strategy to reveal the pathogenesis of emerging pathogens (Boeck Lab)
Studying the genetic and phenotypic bacterial diversity can provide important insights into the biology of bacteria but is so far challenging to analyze.
Lucas Boeck and a team led by Andres Floto (University of Cambridge; UK) have established a new method, combining multi-dimensional phenotyping, computational structural modelling and the study of bacterial coevolution with traditional genome-wide association studies (GWAS). Using their phenogenomic analyses approach, they identified new mechanisms of virulence and resistance in the emerging respiratory pathogen Mycobacterium abscessus.
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