Publications

Schaefer, T., Zajonz, A., Lorentz, P., Bohnacker, T., Wymann, M. P. and Schweighoffer, T. (2012) ‘Luminal decoration of blood vessels by activated perivasal mast cells in allergic rhinitis’, Allergy. Munksgaard, 67(4), pp. 510-520. doi: 10.1111/j.1398-9995.2012.02790.x.   edoc
Anzinger, J. J., Chang, J., Xu, Q., Barthwal, M. K., Bohnacker, T., Wymann, M. P. and Kruth, H. S. (2012) ‘Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3K?-dependent fluid-phase pinocytosis of native LDL’, Journal of Lipid Research. American Society for Biochemistry and Molecular Biology, 53(1), pp. 34-42. doi: 10.1194/jlr.M018887.   edoc | Open Access
Wymann, M. (2012) ‘PI3Ks-drug targets in inflammation and cancer’, Subcellular biochemistry. Springer, Vol. 58, pp. 111-181. doi: 10.1007/978-94-007-3012-0_5.   edoc
Reichel, C. A., Lerchenberger, M., Uhl, B., Rehberg, M., Berberich, N., Zahler, S., Wymann, M. P. and Krombach, F. (2011) ‘Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature’, PLoS ONE. Public Library of Science, 6(2), p. e17229. doi: 10.1371/journal.pone.0017229.   edoc
Becattini, B., Marone, R., Zani, F., Arsenijevic, D., Seydoux, J., Montani, J.-P., Dulloo, A. G., Thorens, B., Preitner, F., Wymann, M. P. and Solinas, G. (2011) ‘PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance’, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 108(42), pp. E854-63. doi: 10.1073/pnas.1106698108.   edoc
Perino, A., Ghigo, A., Ferrero, E., Morello, F., Santulli, G., Baillie, G. S., Damilano, F., Dunlop, A. J., Pawson, C., Walser, R., Levi, R., Altruda, F., Silengo, L., Langeberg, L. K., Neubauer, G., Heymans, S., Lembo, G., Wymann, M. P., Wetzker, R., Houslay, M. D., Iaccarino, G., Scott, J. D. and Hirsch, E. (2011) ‘Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ’, Molecular cell. Cell Press, 42(1), pp. 84-95. doi: 10.1016/j.molcel.2011.01.030.   edoc
Wymann, M. P. and Wenk, M. R. (2011) ‘Neutral not a loss : phosphoinositides beyond the head group’, Nature methods. Nature Publishing Group, 8(3), pp. 219-220. doi: 10.1038/nmeth0311-219.   edoc
Spitzenberg, V., König, C., Ulm, S., Marone, R., Röpke, L., Müller, J. P., Grün, M., Bauer, R., Rubio, I., Wymann, M. P., Voigt, A. and Wetzker, R. (2010) ‘Targeting PI3K in neuroblastoma’, Journal of cancer research and clinical oncology. Springer, 136(12), pp. 1881-1890. doi: 10.1007/s00432-010-0847-2.   edoc
Ciraolo, E., Morello, F., Hobbs, R. M., Wolf, F., Marone, R., Iezzi, M., Lu, X., Mengozzi, G., Altruda, F., Sorba, G., Guan, K., Pandolfi, P. P., Wymann, M. P. and Hirsch, E. (2010) ‘Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility’, Molecular Biology of the Cell. American Society for Cell Biology, 21(5), pp. 704-711. doi: 10.1091/mbc.E09-08-0744.   edoc | Open Access
Thomas, M., Edwards, M. J., Sawicka, E., Duggan, N., Hirsch, E., Wymann, M. P., Owen, C., Trifilieff, A., Walker, C., Westwick, J. and Finan, P. (2009) ‘Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation’, Immunology : an official journal of the British Society for Immunology. Blackwell, 126(3), pp. 413-422.   edoc
Bohnacker, T., Marone, R., Collmann, E., Calvez, R., Hirsch, E. and Wymann, M. P. (2009) ‘PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells’, Science signaling : the signal transduction knowledge environment. American Association for the Advancement of Science, 2(74), p. ra27.   edoc
Santos-Sierra, S., Deshmukh, S. D., Kalnitski, J., Küenzi, P., Wymann, M. P., Golenbock, D. T. and Henneke, P. (2009) ‘Mal connects TLR2 to PI3Kinase activation and phagocyte polarization’, The EMBO journal. Nature Publishing Group, 28(14), pp. 2018-2027.   edoc
Kurig, B., Shymanets, A., Bohnacker, T., Prajwal, Brock, C., Ahmadian, M. R., Schaefer, M., Gohla, A., Harteneck, C., Wymann, M. P., Jeanclos, E. and Nürnberg, B. (2009) ‘Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma’, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 106(48), pp. 20312-20317.   edoc
Barberis, L., Pasquali, C., Bertschy-Meier, D., Cuccurullo, A., Costa, C., Ambrogio, C., Vilbois, F., Chiarle, R., Wymann, M., Altruda, F., Rommel, C. and Hirsch, E. (2009) ‘Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin’, European journal of immunology. Verl. Chemie, 39(4), pp. 1136-1146.   edoc
Marone, R., Erhart, D., Mertz, A. C., Bohnacker, T., Schnell, C., Cmiljanovic, V., Stauffer, F., Garcia-Echeverria, C., Giese, B., Maira, S.-M. and Wymann, M. P. (2009) ‘Targeting melanoma with dual phosphoinosite 3-kinase/mammalian target of rapamycin inhibitors’, Molecular Cancer Research. AACR, 7(4), pp. 601-613.   edoc
Wymann, M. P. and Schneiter, R. (2008) ‘Lipid signalling in disease’, Nature reviews. Molecular cell biology. Nature Publishing Group, 9(2), pp. 162-176.   edoc
Ciraolo, E., Iezzi, M., Marone, R., Marengo, S., Curcio, C., Costa, C., Azzolino, O., Gonella, C., Rubinetto, C., Wu, H., Dastrù, W., Martin, E. L., Silengo, L., Altruda, F., Turco, E., Lanzetti, L., Musiani, P., Rückle, T., Rommel, C., Backer, J. M., Forni, G., Wymann, M. P. and Hirsch, E. (2008) ‘Phosphoinositide 3-kinase p110beta activity : key role in metabolism and mammary gland cancer but not development’, Science signaling. American Association for the Advancement of Science, 1(36), p. ra3.   edoc
Marone, R., Cmiljanovic, V., Giese, B. and Wymann, M. P. (2008) ‘Targeting phosphoinositide 3-kinase-Moving towards therapy’, Biochimica et biophysica acta. Elsevier, 1784(1), pp. 159-185.   edoc
Fougerat, A., Gayral, S., Gourdy, P., Schambourg, A., Rückle, T., Schwarz, M. K., Rommel, C., Hirsch, E., Arnal, J. F., Salles, J. P., Perret, B., Breton-Douillon, M., Wymann, M. P. and Laffargue, M. (2008) ‘Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes’, Circulation. Lippincott Williams & Wilkins, 117(10), pp. 1310-1317.   edoc
Hui, R. C., Gomes, A. R., Constantinidou, D., Costa, J. R., Karadedou, C. T., Fernandez de Mattos, S., Wymann, M. P., Brosens, J. J., Schulze, A. and Lam, E. W. (2008) ‘The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression’, MOL CELL BIOL, 28, pp. 5886-5898.