Selected Publications

Peer-reviewed journals

1.    Stehle S, Rückert T, Fiancette R, Gajdasik DW, Willis C, Ulbricht C, Durek P, Mashreghi MF, Finke D, Hauser AE, Withers DR, Chang HD, Zimmermann J and Romagnani C. 2021. T-bet and RORa control lymph node formation by regulating embryonic innate lymphoid cell differentiation. Nature Immunology, in press.

2.    Teufel C, Horvath E, Peter A, Ercan C, Piscuoglio S, Hall MN, Finke D* and Lehmann FM*. 2021. mTOR signaling mediates ILC3-driven immunopathology. Mucosal Immunology, DOI.

3.    Lehmann FM*, von Burg N*, Ivanek R, Teufel C, Horvath E, Peter A, Turchinovich G, Staehli D, Eichlisberger T, Gomez de Aguero M, Coto Llerena M, Prchal-Murphy M, Sexl V, Bentires-Alj M, Mueller C, Finke D. 2020. Microbiota-induced signals regulate ILC3-mediated antigen presentation. Nature communications, 11, 1794. doi: 10.1038/s41467-020-15612-2.

4.    Li Y, Masse-Ranson G, Garcia Z, Bruel T, Kök A, Strick-Marchand H, Jouvion G, Serafini N, Lim AI, Dusseaux M, Hieu T, Bourgade F, Toubert A, Finke D, Schwartz O, Bousso P, Mouquet H and Di Santo JP. 2018. A human immune system mouse model with robust lymph node development. Nat. methods. 15, 623-630.

5.    Turchinovich G, Ganter S, Bärenwaldt A and Finke D. 2018. NKp46 calibrates tumoricidal potential of type 1 innate lymphocytes by regulating TRAIL expression. J. Immunol. 200, 3762-3768.

6.    Raykova A, Carrega P, Lehmann FM, Ivanek R, Landtwing V, Quast I, Lünemann JD, Finke D, Ferlazzo G, Chijioke O, Münz C. 2017. Interleukin 12 and 15 induce cytotoxicity and early NK-cell differentiation in type 3 innate lymphoid cells. Blood Adv. 1, 2679-2691.

7.    Dalmas E, Lehmann FM, Dror E, Wueest S, Thienel C, Borsigova M, Stawiski M, Traunecker E, Lucchini FC, Dapito DH, Kallert SM, Guigas B, Pattou F, Kerr-Conte J, Maechler P, Girard JP, Konrad D, Wolfrum C, Böni-Schnetzler M, Finke D, Donath MY. 2017. Interleukin-33-activated islet-resident innate lymphoid cells promote insulin secretion through myeloid cell retinoic acid production. Immunity, 47, 928-947.

8.    Von Muenchow L, Alberti-Servera  L, Klein F, Capoferri G, Finke D, Ceredig R, Rolink A, Tsapogas P. 2016. Permissive roles of cytokines Interleukin-7 and Flt3-ligand in mouse B cell lineage commitment. PNAS, 113, E8122-E8130.

9.    Bank U, Deiser K, Finke D, Hämmerling GJ, Arnold B and Schüler T. 2016. Cutting edge: innate lymphoid cells suppress homeostatic T cell expansion in neonatal mice. J. Immunol., 196, 3532-6.

10.    Baerenwaldt A, von Burg N, Kreuzaler M, Sitte S, Horvath E, Peter A, Voehringer D, Rolink AG and Finke D. 2016. Flt3 Ligand regulates the development of innate lymphoid cells in fetal and adult mice. J. Immunol., 196 (6):2561-71.

11.    Schmaler M, Broggi MA, Lagarde N, Stöcklin BF, King CG, Finke D and Rossi SW. 2015, IL-7R signalling in regulatory T cells maintains peripheral and allograft tolerance in mice. PNAS, 112 (43):13330-5.

12.    Brasseit J, Althaus-Steiner E, Faderl M, Dickgreber N, Saurer L, Genitsch V, Dolowschiak T, Li H, Finke D, Hardt WD, McCoy KD, Macpherson AJ, Corazza N, Noti M, Mueller C. 2015. CD4 T cells are required for both development and maintence of disease in a new mouse model of reversible colitis. Mucosal Immunology, 9, 689-701.

13.    Von Burg N, Chappaz S, Baerenwaldt A, Horvath E, Dasgupta SB, Ashok D, Pieters J, Tacchini-Cottier F, Rolink H, Acha-Orbea H and Finke D. 2014. Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses. PNAS, 111(35): 12835-40.

14.    Iolyeva M, Aebischer D, Ecoiffier T, Häner S, Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O, Chen L, Finke D and Halin C. 2013. Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage. Blood, 122(13):2271-81.

15.    Zuklys S, Mayer CE, Zhanybekova S, Stefanski HE, Nusspaumer G, Gill J, Barthlott T, Chappaz S, Nitta T, Dooley J, Nogales-Cadenas R, Takahama Y, Finke D, Liston A, Blazar BR, Pascual-Montano A, Holländer GA. 2012. MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection. J Immunol, 189(8):3894-904.

16.    Shalapour S, Deiser K, Kühl AA, Glauben R, Krug SM, Fischer A, Sercan O, Chappaz S, Bereswill S, Heimesaat MM, Loddenkemper C, Fromm M, Finke D, Hämmerling GJ, Arnold B, Siegmund B, Schüler T. 2012. Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis. PLoS One. 7(2):e31939. 

17.    Kiss EA, Vonarbourg C, Kopfmann S, Hobeika E, Finke D, Esser C, Diefenbach A. 2011. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science. 334(6062):1561-65.

18.    Vonarbourg C, Mortha A, Bui VL, Hernandez PP, Kiss EA, Hoyler T, Flach M, Bengsch B, Thimme R, Hölscher C, Hönig M, Pannicke U, Schwarz K, Ware CF, Finke D, Diefenbach A. 2010. Regulated expression of nuclear receptor RORgt confers distinct functional fates to NK cell receptor-expressing RORgt(+) innate lymphocytes. Immunity. 24;33(5):736-51.

19.    Chappaz S, Gärtner C, Rodewald HR, Finke D. 2010. Kit ligand and Il7 differentially regulate Peyer’s patch and lymph node development. J Immunol.;185(6):3514-19.

20.    Chappaz S, Finke D. 2010. The IL-7 signaling pathway regulates lymph node development independent of peripheral lymphocytes. J Immunol. 1;184(7):3562-69.

21.    Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, Radtke F. 2010. Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch  signaling in the murine skin. PLoS One. 18;5(2):e9258.

22.    Schmutz, S., N. Bosco, S. Chappaz, O. Boyman, H. Acha-Orbea, R. Ceredig, A.G. Rolink and D.    Finke. 2009. Cutting edge: Interleukin 7 regulates the peripheral pool of adult ROR + lymphoid tissue inducer cells. JI, 183, 2217-2221.

23.    Elentner, A., D. Finke, M. Schmuth, S. Ebner, P. Chambon, B. Malissen, A. Kissenpfennig, N. Romani and S. Dubrac. 2009. Langerhans cells are critical in the development of atopic dermatitis-like inflammation and symptoms in mice. Journal of Cellular and Molecular Medicine, 13(8B): 2657-72.

24.    Vogt, T.K., J. Perrin, D. Finke and S.A. Luther. 2009. Novel function for interleukin 7 in dendritic cell development and maintenance. Blood, 113, 3961-3968. 25.    Combaluzier, B., J. Massner, D. Finke and J. Pieters. 2009. Coronin 1 is essential for IgM mediated Ca2+ mobilization in B cells but dispensable for in vivo B cell function. J. Immunol., 182, 1954-61.

26.    Scandella, E., B. Bollinger, E. Lattmann, S. Miller, S. Favre, D.R. Littman, D. Finke, S.A. Luther, T. Junt and B. Ludewig. 2008. Restoration of lymphoid organ integrity through interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nature Immunology, 9, 667-675.

27.    White, A.J., D.R. Withers, S.M. Parnell, H.S. Scott, D. Finke, P.J. Lane, E.J. Jenkinson and G. Anderson. 2008. Sequencial phases in the development of aire-expressing medullary epithelial cells involve distinct cellular input. European Journal of Immunology, 38, 1-6.

28.    Chappaz, S., L. Flueck, A.G. Farr, A.G. Rolink and D. Finke. 2007. Increased TSLP availability restores T and B cell compartments in adult IL-7-deficient mice. Blood, 110, 3862-70.

29.    Meier, D., C. Bornmann, S. Chappaz, S. Schmutz, L.A. Otten, R. Ceredig, H. Acha-Orbea and D.    Finke. 2007. Ectopic lymphoid-organ development occurs through interleukin-7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity, 26, 643-654.

30.    Rumbo, M., F. Sierro, N. Debard, J.P. Kraehenbuhl, D. Finke. 2004. Lymphotoxin   receptor signaling induces the chemokine CCL20 in intestinal epithelium. Gastroent. 127, 213-223.

31.    Esslinger, C., L. Chapatte, D. Finke, I. Miconnet, P. Guillaume, F. Lévy, H.R. MacDonald. 2003. In vivo administration of a lentiviral vaccine targets dendritic cells and induces efficient CD8+ T cell responses, J. Clin. Inv., 111, 1673-1681.

32.    Capone, M., R.K. Lees, D. Finke, B. Ernst, J.P.M. Van Meerwijk, H.R. MacDonald. 2003. Selective absence of CD8+TCR  + intestinal epithelial cells in transgenic mice expressing  2 microglobulin-associated ligands exclusively on thymic cortical epithelium. Eur. J. Immunol.,

33, 1471-1477. 33.    Ramirez, J.C. *, Finke, D.*, J.P. Kraehenbuhl, M. Esteban, H. Acha-Orbea. 2003. Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administration. Arch. Virol., 148, 827-839. *equal contribution

34.    Mpandi, M., L.A. Otten, C. Lavanchy, H. Acha-Orbea, D. Finke. 2003. Passive immunization with neutralizing antibodies interrupts the mouse mammary tumor virus life cycle. J. Virol., 77, 9369-9377.

35.    Finke. D., S. Luther, H. Acha-Orbea. 2003. The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development. PNAS, 100, 199-204.

36.    Finke, D., H. Acha-Orbea, A. Mattis, M. Lipp, J.P. Kraehenbuhl, 2002. CD4+CD3- cells induce Peyer’s patch development: role of  4 1-integrin-activation by CXCR5. Immunity, 17, 363-373.

37.    Wehrli, N., Legler, D.F., D. Finke, K.-M. Toellner, P. Loetscher, M. Baggiolini, J.C.M. MacLennan, H. Acha-Orbea. 2001. Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes. Eur. J. Immunol. 31, 609-616.

38.    Finke, D., F. Baribaud, H. Diggelmann, H. Acha-Orbea. 2001. Extrafollicular plasmablast B cells play a key role in carrying retroviral infection to peripheral organs. J. Immunol., 166, 6276-6286.

39.    Finke, D. and H. Acha-Orbea. 2001. Differential migration of in vivo primed B and T lymphocytes to lymphoid and non-lymphoid organs. Eur. J. Immunol., 31, 2603-2611.

40.    Schneider, P., H. Takatsuka, A. Wilson, F. Mackay, A. Tardivel, S. Lens, T.G. Cachero, D. Finke, F. Beermann, J. Tschopp.2001. Maturation of marginal zone and follicular B cells requires B cell activation factor of the tumor necrosis factor family and is independent of B cell maturation antigen. J. Exp. Med., 194, 1691-1697.

41.    Astori, M. *, Finke, D.*, O. Karapetian, H. Acha-Orbea. 1999. Development of T cell/B cell collaboration in neonatal mice. Int. Immunol., 11, 445-451. *equal contribution

42.    Finke, D., L. Mortezawi, H. Acha-Orbea. 1998. Preactivation of B lymphocytes does not enhance mouse mammary tumor virus infection. J. Virol., 72, 7688-7691.

43.    Finke, D., U.G. Brinckmann, V. ter Meulen, U.G. Liebert. 1995. Gamma Interferon is a major mediator of the antiviral defense in experimental measles virus-induced encephalitis. J. Virol., 69, 5469-5474. 44.    Finke, D., U.G. Liebert, V. ter Meulen. 1994. CD4+ T Lymphocytes are essential in overcoming experimental murine measles encephalitis. Immunology, 83, 184-189.

Reviews/Book chapters

1.    Von Burg, N, G. Turchinovich and D. Finke. 2015. Maintenance of immune homeostasis through ILC/T cell interactions. Frontiers in Immunology, 6, 416

2.    Finke D. 2009. The induction of intestinal lymphoid tissue formation by intrinsic and extrinsic signals. Seminars in Immunopathology, 31, 151-69.

3.    Chappaz, S and D. Finke. 2009. The biology of lymphoid tissue inducer cells. In: Cell Determination During Hematopoiesis, chapter 9, novapublisher ISBN, 978-1-60741-733-0.

4.    Finke, D. and Sandrine Schmutz. 2008. Interleukin 7 induced lymphoid neogenesis in arthritis: recapitulation of a fetal developmental program? Swiss Med. Weekly, 138, 500-505.

5.    Finke, D. 2008 An immunologist’s view on establishment of a knowledge dialogue. In: A Vision of Transdisciplinarity; Laying Foundations for a World Knowledge Dialogue, Eds. F. Darbellay, M. Cockell, J. Billotte and F. Waldvogel, EPFL press, Lausanne, Switzerland, 75-84.

6.    H. Acha-Orbea, A.N. Shakhov and D. Finke. 2007. Immune response to MMTV infection. Frontiers in Bioscience 12, 1594-1609.

7.    Finke, D. and D. Meier. 2006. Molecular networks orchestrating GALT development. Current Topics in Microbiology and Immunology, 308, 19-57.

8.    Finke, D. 2005. Fate and function of lymphoid tissue inducer cells. Current Opinion in Immunology, 17, 144-150.

9.    M. Rumbo, P. Anderle, A. Didierlaurant, F. Sierro, N. Debard, JC Sirard, D. Finke and J.P. Kraehenbuhl. 2004. How the gut links innate and adaptive immunity. Annals of the New York Academy of Sciences, 1029, 16-21.

10.    Otten, L, D. Finke, H. Acha-Orbea. 2002. Toll-like receptor 4 and mouse mammary tumor virus: a paradigm for virus-host interactions. Trends in Microbiology, 10, 303-305.

11.    Finke, D. and J.P. Kraehenbuhl. 2001. Formation of Peyer's Patches. Curr. Opin. Gen. Develop. Biol., 11, 561-567.

12.    Finke, D. and H. Acha-Orbea. 2001, Immune response to murine and feline retroviruses. In: Retroviral Immunology, Eds. G. Pantaleo & B.D. Walker, Humana Press, New York, NY. page 125-    157.

13.    H. Acha-Orbea, D. Finke, A. Attinger, S. Schmid, N. Wehrli, S. Vacheron, I Xenarios, K.M. Toellner, I.C.M. MacLennan, S. Luther. 1999. Interplays between mouse mammary tumor virus and the cellular and humoral immune response. Immunol. Rev., 168, 287-303.

14. Liebert, U.G, D. Finke. 1994. Measles virus infections in rodents. Current topics in microbiology and immunology. V. ter Meulen and M. Billeter, editors, Springer-Verlag, Berlin, 149-66.