Selected Publications
Schwarz SD., Xu J., Gunasekera K., Schürmann D., Vågbø CB., Ferrari E., Slupphaug G., Hottiger MO., Schär P., Steinacher R. (2024). Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation. Nat Commun. 15:184.
Noreen, F., Chaber-Ciopinska, A., Regula, J., Schär, P., and Truninger, K. (2020) Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging. Clin Epigenetics 12, 164.
Steinacher/ R., Barekati, Z., Botev, P., Kuśnierczyk, A., Slupphaug, G. & Schär, P. (2019) SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation. EMBO J.:e99242 > News & Views
Schuermann, D., Scheidegger, SP., Weber, AR., Bjørås, M., Leumann, CJ., and Schär P. (2016) 3CAPS – a structural AP-site analogue as a tool to investigate DNA base excision repair. Nucleic Acids Res 44, 2187–2198
Weber, AR., Krawczyk, C., Robertson, AB., Kusnierczyk, A., Vågbø, CB., Schuermann, D., Klungland, A., and Schär, P. (2016 ) Biochemical reconstitution of TET1-TDG-BER-dependentactive DNA demethylation reveals a highly coordinated mechanism. Nat Commun 7, 10806
Noreen, F., Röösl,i M., Gaj, P., Pietrzak, J., Weis, S., Urfer, P., Regula, J., Schär P., and Truninger K. (2014) Modulation of age and cancer-associated DNA methylation change in the healthy colon by aspirin and lifestyle. JNCI J (2014) 106(7): dju161.
Cortazar, D., Kunz, C., Selfridge, J., Lettieri, T., Saito, Y., Macdougall, E., Wirz, A., Schuermann, D., Jacobs, A. L., Siegrist, F., Steinacher, R., Jiricny, J., Bird, A., and Schär, P. (2011). Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature 470, 419-423.
Kunz, C., Focke, F., Saito, Y., Schuermann, D., Lettieri, T., Selfridge, J., and Schär, P. (2009). Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil. PLoS Biol 7, e91.
Hardeland, U., Steinacher, R., Jiricny, J., and Schär, P. (2002). Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. EMBO J, 1456-1464.
Valencia, M., Bentele, M., Vaze, M. B., Herrmann, G., Kraus, E., Lee, S. E., Schär, P., and Haber, J. E. (2001). NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae. Nature 414, 666-669. (joint publication with Haber lab)