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Inflammation rewires the bone marrow microenvironment long before leukemias develop (Zaugg Lab)

The bone marrow continuously produces new blood and immune cells through coordinated signals between stem cells, stromal cells, and immune regulators. Aging, inflammation, or mutations can disrupt this balance, allowing mutated stem cells…

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/ News, Research

Human bone marrow model paves the way to reduce animal testing (Martin Lab)

Big news from our Tissue Engineering lab! The lab has taken an important step toward developing research methods that rely less on animal experiments, and have created a highly complex model of the bone marrow in the laboratory made…

Microscopy images showing three separate areas of a lung tumor, representing different immune environments: desert, excluded, and inflamed. These are general examples used to illustrate how immune cells interact with tumors. The top row displays a CD8 immunohistochemistry image, while the bottom row shows a marked version where CD8+ T cells are highlighted in red and tumor cells in blue. Adopted from Schmid, D., et al. (2025), Nature Communications.
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New insights into tumor-immune dynamics predict long-term outcomes in stage IIIA NSCLC patients receiving neoadjuvant chemoimmunotherapy (Zippelius Lab)

Lung cancer remains one of the most lethal malignancies worldwide, and for patients diagnosed with locally advanced non-small cell lung cancer (NSCLC), treatment options are often limited and still pose major uncertainties for patients and…

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Department of Biomedicine Newsletter No. 11

We are pleased to announce the release of the eleventh edition of our DBM newsletter. We hope you enjoy reading it!

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/ News, Research

Combining Forces: Fusion Protein Boosts Immune Attack on Cancer (Zippelius Lab)

Harnessing the body’s immune system has transformed cancer treatment, yet current immunotherapies are often limited by toxicity or by the ability of tumors to silence immune cells. A new study from Irene Fusi and Clara Serger et al. in…

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