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Microscopy images showing three separate areas of a lung tumor, representing different immune environments: desert, excluded, and inflamed. These are general examples used to illustrate how immune cells interact with tumors. The top row displays a CD8 immunohistochemistry image, while the bottom row shows a marked version where CD8+ T cells are highlighted in red and tumor cells in blue. Adopted from Schmid, D., et al. (2025), Nature Communications.
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New insights into tumor-immune dynamics predict long-term outcomes in stage IIIA NSCLC patients receiving neoadjuvant chemoimmunotherapy (Zippelius Lab)

Lung cancer remains one of the most lethal malignancies worldwide, and for patients diagnosed with locally advanced non-small cell lung cancer (NSCLC), treatment options are often limited and still pose major uncertainties for patients and…

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Department of Biomedicine Newsletter No. 11

We are pleased to announce the release of the eleventh edition of our DBM newsletter. We hope you enjoy reading it!

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/ News, Research

Combining Forces: Fusion Protein Boosts Immune Attack on Cancer (Zippelius Lab)

Harnessing the body’s immune system has transformed cancer treatment, yet current immunotherapies are often limited by toxicity or by the ability of tumors to silence immune cells. A new study from Irene Fusi and Clara Serger et al. in…

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A Step Forward in Precision Medicine: Novel BiTE Immunotherapy for High-Risk CLL (Binder Lab)

Chronic lymphocytic leukemia (CLL) is a malignant B-cell disease whose course is strongly influenced by the configuration of the B-cell receptor (BCR). A well-known high-risk marker is the IGLV3-21-R110 mutation, found in about 10–15% of…

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ERC Starting Grants Awarded to Four DBM Researchers

"What if we could re-energize exhausted immune cells to fight cancer again? Or slow down the aging process of our immune system? What if we could stop breast cancer from spreading? What if there were better cellular immunotherapies to fight…

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